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Tdark
KIAA1522
Uncharacterized protein KIAA1522

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294521
  • ENSP00000294521
  • ENSG00000162522
  • ENST00000373480
  • ENSP00000362579
  • ENST00000373481
  • ENSP00000362580
  • ENST00000401073
  • ENSP00000383851
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
cellular component
0.92
ligand (protein) perturbation
0.83
transcription factor
0.82
transcription factor perturbation
0.8


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.54   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.54   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (24)
NCK1
Tbio
Novelty:  0.00352084
p_int:  0.99999995
p_ni:  5e-8
Data Source:  BioPlex
NCKAP1
Tbio
Novelty:  0.03486454
p_int:  0.999999648
p_ni:  3.52e-7
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.999998953
p_ni:  0.000001047
Score:  0.282
Data Source:  BioPlex,STRINGDB
ABI2
Tbio
Novelty:  0.02324355
p_int:  0.999997609
p_ni:  0.000002391
Score:  0.625
Data Source:  BioPlex,STRINGDB
BAIAP2
Tbio
Novelty:  0.00949996
p_int:  0.999982283
p_ni:  0.000017706
p_wrong:  1.1e-8
Score:  0.868
Data Source:  BioPlex,STRINGDB
NCK2
Tbio
Novelty:  0.02220251
p_int:  0.999933476
p_ni:  1.27e-7
p_wrong:  0.000066398
Score:  0.79
Data Source:  BioPlex,STRINGDB
ARHGAP12
Tbio
Family:  Enzyme
Novelty:  0.12113722
p_int:  0.999169168
p_ni:  0.000830759
p_wrong:  7.3e-8
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.990820399
p_ni:  0.009172043
p_wrong:  0.000007559
Data Source:  BioPlex
KLHL31
Tbio
Novelty:  0.10153296
Score:  0.575
Data Source:  STRINGDB
GPR6
Tchem
Family:  GPCR
Novelty:  0.05964344
Score:  0.573
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
60.2
body mass index
1
1
1
59
visceral adipose tissue measurement
1
1
1
33.1
1
1
1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
60.2
body mass index
1
59
visceral adipose tissue measurement
1
33.1
1
2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KIAA1522
VGNC:6904
743096
Macaque
KIAA1522 ortholog
708903
Mouse
MGI:2140651
97130
Rat
RGD:1561149
500552
Horse
KIAA1522
VGNC:19381
100070149
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KIAA1522
Macaque
KIAA1522 ortholog
Mouse
Rat
Horse
KIAA1522
Publication Statistics
PubMed Score 9.54
PubMed score by year
PubTator Score 2.92
PubTator score by year
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Related Publications
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PMID
Year
Title