You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KIAA1109
Transmembrane protein KIAA1109

Protein Summary
Description
This gene is located on the long arm of chromosome 4 in a region that is associated with susceptibility to celiac disease. The encoded protein is similar to a Chinese hamster protein that is associated with spermatocyte and adipocyte differentiation. The C-terminus of the protein is also similar to a Caenorhabditis elegans protein that plays a role in lipid storage. In mammals, this protein is thought to function in the regulation of epithelial growth and differentiation, and in tumor development. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264501
  • ENSP00000264501
  • ENSG00000138688
  • ENST00000388738
  • ENSP00000373390

Symbol
  • FSA
  • KIAA1371
  • FSA
  • Tweek
  • ALKKUCS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.88
transcription factor perturbation
0.8
phenotype
0.78
tissue sample
0.66
cell type or tissue
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.42   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 15   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.42   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 15   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
CCDC28A
Tdark
Novelty:  0.47441753
p_int:  0.999999996
p_ni:  3e-9
Data Source:  BioPlex
ADAD1
Tbio
Family:  Enzyme
Novelty:  0.05906067
Score:  0.757
Data Source:  STRINGDB
HUWE1
Tbio
Family:  Enzyme
Novelty:  0.01104129
Score:  0.753
Data Source:  STRINGDB
TRRAP
Tbio
Novelty:  0.01517245
Score:  0.692
Data Source:  STRINGDB
LGALS1
Tchem
Novelty:  0.00106509
Score:  0.641
Data Source:  STRINGDB
ALS2CL
Tbio
Novelty:  0.28104121
Score:  0.594
Data Source:  STRINGDB
VPS13D
Tdark
Novelty:  0.12578583
Score:  0.588
Data Source:  STRINGDB
PRPF8
Tbio
Novelty:  0.01717158
Score:  0.585
Data Source:  STRINGDB
WDFY3
Tbio
Novelty:  0.01670166
Score:  0.578
Data Source:  STRINGDB
TRIM44
Tbio
Novelty:  0.00483553
Score:  0.569
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
2
1.5
98.1
asthma
9
9
1
1.1
98
allergic disease
6
5
3
1.1
97.4
4
2
2
3.7
95.5
2
3
0
1.1
92.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.5
98.1
asthma
1
1.1
98
allergic disease
3
1.1
97.4
2
3.7
95.5
0
1.1
92.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KIAA1109
VGNC:623
461469
Mouse
MGI:2444631
229227
Dog
KIAA1109
VGNC:42357
483843
Horse
KIAA1109
VGNC:19371
100063889
Pig
KIAA1109 ortholog
100521104
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KIAA1109
Mouse
Dog
KIAA1109
Horse
KIAA1109
Pig
KIAA1109 ortholog
Publication Statistics
PubMed Score 68.42
PubMed score by year
PubTator Score 27.66
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title