Tbio KIAA0391 Mitochondrial ribonuclease P catalytic subunit

Protein Summary

Description

Catalytic ribonuclease component of mitochondrial ribonuclease P, a complex composed of TRMT10C/MRPP1, HSD17B10/MRPP2 and MRPP3, which cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:25953853). The presence of TRMT10C/MRPP1, HSD17B10/MRPP2 is required to catalyze tRNA molecules in their 5'-ends (PubMed:25953853).

Uniprot Accession IDs

• O15091
• B4DXD9
• B4E0S8
• B4E211
• C4AM93
• D3DS99
• D3DSA1
• Q86SZ4
• Q86YB5
• Q8N5L5

Gene Name

• KIAA0391

Ensembl ID

• ENST00000250377
• ENSP00000250377
• ENSG00000100890
• ENST00000321130
• ENSP00000324697
• ENST00000534898
• ENSP00000440915
• ENST00000603544
• ENSP00000473856
• ENST00000604948
• ENSP00000474620
• ENST00000605870
• ENSP00000474299

Symbol

• MRPP3
• MRPP3
• PRORP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.97
histone modification site profile	0.89
transcription factor binding site profile	0.71
tissue sample	0.65
tissue	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.02   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.02   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0