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Tbio
KERA
Keratocan

Protein Summary
Description
May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix. The protein encoded by this gene is a keratan sulfate proteoglycan that is involved in corneal transparency. Defects in this gene are a cause of autosomal recessive cornea plana 2 (CNA2).[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266719
  • ENSP00000266719
  • ENSG00000139330

Symbol
  • SLRR2B
  • KTN
  • CNA2
  • SLRR2B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.93
cell type or tissue
0.82
gene perturbation
0.61
cell line
0.59
cellular component
0.53


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.14   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.14   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (78)
NUDT12
Tbio
Family:  Enzyme
Novelty:  0.18740719
p_int:  0.999999988
p_ni:  1.1e-8
p_wrong:  1e-9
Score:  0.76
Data Source:  BioPlex,STRINGDB
CNPY4
Tdark
Novelty:  0.59578334
p_int:  0.999997001
p_ni:  8.42e-7
p_wrong:  0.000002157
Score:  0.195
Data Source:  BioPlex,STRINGDB
VWA8
Tdark
Novelty:  0.17546432
p_int:  0.999536841
p_ni:  0.000463159
Score:  0.537
Data Source:  BioPlex,STRINGDB
EID2
Tbio
Novelty:  0.02022264
p_int:  0.998633831
p_ni:  0.000005253
p_wrong:  0.001360915
Score:  0.319
Data Source:  BioPlex,STRINGDB
FBXO21
Tbio
Novelty:  0.2186203
p_int:  0.996756472
p_ni:  0.003243528
Score:  0.188
Data Source:  BioPlex,STRINGDB
BLMH
Tbio
Family:  Enzyme
Novelty:  0.00855614
p_int:  0.990459728
p_ni:  0.009540272
Score:  0.874
Data Source:  BioPlex,STRINGDB
SQSTM1
Tbio
Novelty:  0.00100555
p_int:  0.979900907
p_ni:  0.020099093
Score:  0.202
Data Source:  BioPlex,STRINGDB
MAP3K7
Tchem
Family:  Kinase
Novelty:  0.00540177
p_int:  0.957008177
p_ni:  0.042989198
p_wrong:  0.000002625
Score:  0.255
Data Source:  BioPlex,STRINGDB
B4GALT5
Tbio
Family:  Enzyme
Novelty:  0.04538678
p_int:  0.942658562
p_ni:  0.053523639
p_wrong:  0.0038178
Score:  0.91
Data Source:  BioPlex,STRINGDB
PRKCI
Tchem
Family:  Kinase
Novelty:  0.0076377
p_int:  0.849991603
p_ni:  0.150007984
p_wrong:  4.13e-7
Score:  0.265
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (R-HSA-3656244)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Reactome
Defective CHST6 causes MCDC1
Reactome
Defective ST3GAL3 causes MCT12 and EIEE15
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Disease
Diseases associated with glycosaminoglycan metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
2
1
0
3
15.6
intraocular pressure measurement
1
1
1
5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
central corneal thickness
0
3
15.6
intraocular pressure measurement
1
5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
keratocan
VGNC:5439
467089
Mouse
MGI:1202398
16545
Rat
RGD:1305816
314771
Dog
keratocan
VGNC:42334
482598
Horse
keratocan
VGNC:19347
100063705
Species
Name
OMA
EggNOG
Inparanoid
Chimp
keratocan
Mouse
Rat
Dog
keratocan
Horse
keratocan
Publication Statistics
PubMed Score 136.14
PubMed score by year
PubTator Score 43.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title