You are using an outdated browser. Please upgrade your browser to improve your experience.

Tclin
KEAP1
Kelch-like ECH-associated protein 1

Protein Summary
Description
Acts as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome. This gene encodes a protein containing KELCH-1 like domains, as well as a BTB/POZ domain. Kelch-like ECH-associated protein 1 interacts with NF-E2-related factor 2 in a redox-sensitive manner and the dissociation of the proteins in the cytoplasm is followed by transportation of NF-E2-related factor 2 to the nucleus. This interaction results in the expression of the catalytic subunit of gamma-glutamylcysteine synthetase. Two alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provide ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000171111
  • ENSP00000171111
  • ENSG00000079999
  • ENST00000393623
  • ENSP00000377245

Symbol
  • INRF2
  • KIAA0132
  • KLHL19
  • INrf2
  • KLHL19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.97
interacting protein
0.96
protein domain
0.92
virus perturbation
0.92
kinase perturbation
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1896.71   (req: < 5)
Gene RIFs: 213   (req: <= 3)
Antibodies: 642   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1896.71   (req: >= 5)
Gene RIFs: 213   (req: > 3)
Antibodies: 642   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 102
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (494)
CDH5
Tbio
Novelty:  0.00072649
p_int:  0.993334512
p_ni:  0.006665488
Score:  0.151
Data Source:  BioPlex,STRINGDB
DPP9
Tchem
Family:  Enzyme
Novelty:  0.00976924
p_int:  0.989740239
p_ni:  0.010259761
Data Source:  BioPlex
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.984088347
p_ni:  0.015911653
Score:  0.942
Data Source:  BioPlex,STRINGDB
P3H3
Tbio
Family:  Enzyme
Novelty:  0.0010004
p_int:  0.981224285
p_ni:  0.018775715
Score:  0.173
Data Source:  BioPlex,STRINGDB
APP
Tchem
Novelty:  0.00008964
p_int:  0.939809598
p_ni:  0.060190402
Score:  0.331
Data Source:  BioPlex,STRINGDB
CDK13
Tchem
Family:  Kinase
Novelty:  0.03084808
p_int:  0.893803976
p_ni:  0.106196024
Data Source:  BioPlex
NEU2
Tbio
Family:  Enzyme
Novelty:  0.00460828
p_int:  0.893569853
p_ni:  0.106430147
Score:  0.177
Data Source:  BioPlex,STRINGDB
IL17F
Tbio
Novelty:  0.00223549
p_int:  0.858852478
p_ni:  0.141147518
p_wrong:  4e-9
Data Source:  BioPlex
SYNE4
Tbio
Novelty:  0.0739848
p_int:  0.848289623
p_ni:  0.151710377
Data Source:  BioPlex
ZC3H18
Tdark
Novelty:  0.3515546
p_int:  0.84433986
p_ni:  0.15566014
Score:  0.156
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (31)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Deubiquitination
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Deubiquitination
Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (21)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
3
7
8
98.2
total cholesterol measurement
2
6
7
97.4
apolipoprotein B measurement
1
4
4
96.9
red blood cell distribution width
4
5
6
96.4
mean corpuscular volume
1
2
2
86.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
8
98.2
total cholesterol measurement
7
97.4
apolipoprotein B measurement
4
96.9
red blood cell distribution width
6
96.4
mean corpuscular volume
2
86.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
kelch like ECH associated protein 1
VGNC:6634
455706
Macaque
kelch like ECH associated protein 1
720514
Mouse
MGI:1858732
50868
Rat
RGD:621619
117519
Dog
kelch like ECH associated protein 1
VGNC:42332
476713
Species
Name
OMA
EggNOG
Inparanoid
Chimp
kelch like ECH associated protein 1
Macaque
kelch like ECH associated protein 1
Mouse
Rat
Dog
kelch like ECH associated protein 1
Publication Statistics
PubMed Score 1896.71
PubMed score by year
PubTator Score 600.00
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title