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Tbio
KDSR
3-ketodihydrosphingosine reductase

Protein Summary
Description
Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). The protein encoded by this gene catalyzes the reduction of 3-ketodihydrosphingosine to dihydrosphingosine. The putative active site residues of the encoded protein are found on the cytosolic side of the endoplasmic reticulum membrane. A chromosomal rearrangement involving this gene is a cause of follicular lymphoma, also known as type II chronic lymphatic leukemia. The mutation of a conserved residue in the bovine ortholog causes spinal muscular atrophy. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326575
  • ENSP00000312939
  • ENSG00000119537
  • ENST00000406396
  • ENSP00000385083
  • ENST00000645214
  • ENSP00000494352

Symbol
  • FVT1
  • SDR35C1
  • DHSR
  • FVT1
  • EKVP4
  • SDR35C1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
histone modification site profile
0.91
kinase perturbation
0.88
transcription factor perturbation
0.88
microRNA
0.76


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.37   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.37   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (75)
REEP5
Tbio
Novelty:  0.00160455
p_int:  0.977650023
p_ni:  0.022349976
p_wrong:  1e-9
Score:  0.199
Data Source:  BioPlex,STRINGDB
TNFSF18
Tbio
Novelty:  0.01423949
p_int:  0.959696199
p_ni:  0.040303801
Data Source:  BioPlex
RELL1
Tbio
Novelty:  0.28949625
p_int:  0.91195799
p_ni:  0.088042007
p_wrong:  4e-9
Score:  0.193
Data Source:  BioPlex,STRINGDB
IPPK
Tbio
Family:  Enzyme
Novelty:  0.02169701
p_int:  0.847699204
p_ni:  0.152300796
Data Source:  BioPlex
SPTLC1
Tchem
Family:  Enzyme
Novelty:  0.00639691
Score:  0.979
Data Source:  STRINGDB
DEGS1
Tchem
Family:  Enzyme
Novelty:  0.00300325
Score:  0.971
Data Source:  STRINGDB
SPTLC2
Tchem
Family:  Enzyme
Novelty:  0.01236952
Score:  0.971
Data Source:  STRINGDB
SPTLC3
Tbio
Family:  Enzyme
Novelty:  0.03671571
Score:  0.968
Data Source:  STRINGDB
CERS6
Tbio
Family:  TF
Novelty:  0.01956925
Score:  0.966
Data Source:  STRINGDB
ASAH2
Tchem
Family:  Enzyme
Novelty:  0.01413539
Score:  0.965
Data Source:  STRINGDB
Pathways (9)
Metabolism (R-HSA-1430728)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (61)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
1
1
1
90.3
eosinophil count
5
4
7
90.1
sex hormone-binding globulin measurement
8
2
11
7
90
type 2 diabetes mellitus
7
1
4
1.1
89.8
eosinophil percentage of leukocytes
2
3
4
88.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mosaic loss of chromosome Y measurement
1
90.3
eosinophil count
7
90.1
sex hormone-binding globulin measurement
11
7
90
type 2 diabetes mellitus
4
1.1
89.8
eosinophil percentage of leukocytes
4
88.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
3-ketodihydrosphingosine reductase
VGNC:7318
738461
Macaque
3-ketodihydrosphingosine reductase
700476
Mouse
MGI:1918000
70750
Rat
RGD:1307775
360833
Dog
3-ketodihydrosphingosine reductase
VGNC:53728
609655
Species
Name
OMA
EggNOG
Inparanoid
Chimp
3-ketodihydrosphingosine reductase
Macaque
3-ketodihydrosphingosine reductase
Mouse
Rat
Dog
3-ketodihydrosphingosine reductase
Publication Statistics
PubMed Score 43.37
PubMed score by year
PubTator Score 7.09
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title