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Tchem
KDM6B
Lysine-specific demethylase 6B

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity). The protein encoded by this gene is a lysine-specific demethylase that specifically demethylates di- or tri-methylated lysine 27 of histone H3 (H3K27me ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000254846
  • ENSP00000254846
  • ENSG00000132510
  • ENST00000448097
  • ENSP00000412513

Symbol
  • JMJD3
  • KIAA0346
  • JMJD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.8
histone modification site profile
0.78
biological process
0.69
cell type or tissue
0.69
transcription factor perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.78   (req: < 5)
Gene RIFs: 71   (req: <= 3)
Antibodies: 334   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 261.78   (req: >= 5)
Gene RIFs: 71   (req: > 3)
Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 24
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (24)
IOX1
Rendered image for IOX1
GSK-J1
Rendered image for GSK-J1
GSK-J4
Rendered image for GSK-J4
CHEMBL1982368
Rendered image for CHEMBL1982368
compound 3 [PMID: 29633584]
Rendered image for compound 3 [PMID: 29633584]
CHEMBL3753391
Rendered image for CHEMBL3753391
Protein-Protein Interactions (276)
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
Score:  0.981
Data Source:  STRINGDB
HIST1H2BA
Tbio
Novelty:  0.02431803
Score:  0.962
Data Source:  STRINGDB
SUZ12
Tbio
Novelty:  0.00402353
Score:  0.961
Data Source:  STRINGDB
H2AFZ
Tbio
Novelty:  0.00222512
Score:  0.957
Data Source:  STRINGDB
HIST2H2AC
Tbio
Novelty:  0.00065524
Score:  0.955
Data Source:  STRINGDB
HIST2H2BE
Tbio
Novelty:  0.00024381
Score:  0.952
Data Source:  STRINGDB
RBBP4
Tbio
Novelty:  0.01062843
Score:  0.951
Data Source:  STRINGDB
H2AFV
Tbio
Novelty:  0.03561635
Score:  0.95
Data Source:  STRINGDB
RNF2
Tbio
Family:  Enzyme
Novelty:  0.00859204
Score:  0.944
Data Source:  STRINGDB
EED
Tchem
Novelty:  0.00615758
Score:  0.943
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Chromatin modifying enzymes
Chromatin organization
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (25)
Find Similar Targets
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (33)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
5
95.7
hematocrit
2
2
2
88.2
eosinophil count
3
1
3
85.7
hemoglobin measurement
3
2
3
84.2
neutrophil count
1
2
2
83.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
95.7
hematocrit
2
88.2
eosinophil count
3
85.7
hemoglobin measurement
3
84.2
neutrophil count
2
83.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2448492
216850
Rat
RGD:1307629
363630
Dog
lysine demethylase 6B
VGNC:42329
489481
Horse
lysine demethylase 6B
VGNC:19341
100073033
Cow
lysine demethylase 6B
VGNC:30532
100140276
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
lysine demethylase 6B
Horse
lysine demethylase 6B
Cow
lysine demethylase 6B
Publication Statistics
PubMed Score 261.78
PubMed score by year
PubTator Score 115.98
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title