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Tchem
KDM5C
Lysine-specific demethylase 5C

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript vari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375379
  • ENSP00000364528
  • ENSG00000126012
  • ENST00000375383
  • ENSP00000364532
  • ENST00000375401
  • ENSP00000364550
  • ENST00000404049
  • ENSP00000385394
  • ENST00000452825
  • ENSP00000445176

Symbol
  • DXS1272E
  • JARID1C
  • SMCX
  • XE169
  • MRXJ
  • SMCX
  • MRX13
  • MRXSJ
  • XE169
  • MRXSCJ
  • JARID1C
  • DXS1272E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
microRNA
0.75
cell type or tissue
0.71
small molecule perturbation
0.7
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.19   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 152.19   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 95
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (95)
2,4-pyridine dicarboxylic acid
Rendered image for 2,4-pyridine dicarboxylic acid
2-(2-Aminothiazol-4-yl)isonicotinic Acid
Rendered image for 2-(2-Aminothiazol-4-yl)isonicotinic Acid
GSK-J1
Rendered image for GSK-J1
CHEMBL3108958
Rendered image for CHEMBL3108958
CHEMBL3770740
Rendered image for CHEMBL3770740
CHEMBL3771180,CHEMBL3771198
Rendered image for CHEMBL3771180,CHEMBL3771198
CHEMBL3769724
Rendered image for CHEMBL3769724
PBIT
Rendered image for PBIT
Protein-Protein Interactions (212)
CARTPT
Tbio
Novelty:  0.00224864
p_int:  0.99999993
p_ni:  7e-8
Data Source:  BioPlex
IQCN
Tdark
Novelty:  2.74045479
p_int:  0.999958001
p_ni:  0.000041996
p_wrong:  2e-9
Data Source:  BioPlex
SCML4
Tdark
Novelty:  0.88711322
p_int:  0.999674973
p_ni:  0.000324362
p_wrong:  6.65e-7
Score:  0.274
Data Source:  BioPlex,STRINGDB
SPATA1
Tdark
p_int:  0.999168256
p_ni:  0.000831686
p_wrong:  5.8e-8
Data Source:  BioPlex
SSH3
Tbio
Family:  Enzyme
Novelty:  0.11388661
p_int:  0.999114554
p_ni:  0.000885361
p_wrong:  8.4e-8
Score:  0.225
Data Source:  BioPlex,STRINGDB
ZNHIT1
Tbio
Novelty:  0.00390514
p_int:  0.999041299
p_ni:  0.000958695
p_wrong:  6e-9
Data Source:  BioPlex
TRIM35
Tbio
Novelty:  0.03280419
p_int:  0.997974795
p_ni:  0.002025118
p_wrong:  8.7e-8
Score:  0.272
Data Source:  BioPlex,STRINGDB
DEF8
Tdark
Novelty:  0.21146806
p_int:  0.997922044
p_ni:  0.002077929
p_wrong:  2.7e-8
Score:  0.156
Data Source:  BioPlex,STRINGDB
PIAS4
Tbio
Family:  TF
Novelty:  0.01388547
p_int:  0.997920697
p_ni:  0.002079198
p_wrong:  1.05e-7
Data Source:  BioPlex
HLA-F
Tbio
Novelty:  0.01200285
p_int:  0.995361316
p_ni:  0.003245896
p_wrong:  0.001392788
Score:  0.205
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
1
1
42.3
monocyte percentage of leukocytes
1
1
1
30.2
testosterone measurement
1
1
1
21.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
1
42.3
monocyte percentage of leukocytes
1
30.2
testosterone measurement
1
21.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:99781
20591
Dog
lysine demethylase 5C
VGNC:49652
491894
Horse
lysine demethylase 5C
VGNC:49269
100034190
Cow
lysine demethylase 5C
VGNC:49972
281490
Pig
lysine demethylase 5C
100037295
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
lysine demethylase 5C
Horse
lysine demethylase 5C
Cow
lysine demethylase 5C
Pig
lysine demethylase 5C
Publication Statistics
PubMed Score 152.19
PubMed score by year
PubTator Score 63.17
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title