You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KDM5C
Lysine-specific demethylase 5C

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:28262558). Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked cognitive disability. Alternative splicing results in multiple transcript vari ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375379
  • ENSP00000364528
  • ENSG00000126012
  • ENST00000375383
  • ENSP00000364532
  • ENST00000375401
  • ENSP00000364550
  • ENST00000404049
  • ENSP00000385394
  • ENST00000452825
  • ENSP00000445176

Symbol
  • DXS1272E
  • JARID1C
  • SMCX
  • XE169
  • MRXJ
  • SMCX
  • MRX13
  • MRXSJ
  • XE169
  • MRXSCJ
  • JARID1C
  • DXS1272E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
microRNA
0.75
cell type or tissue
0.71
small molecule perturbation
0.7
transcription factor binding site profile
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.76   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 182   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 174.76   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 182   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 96
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0