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Tchem
KDM5B
Lysine-specific demethylase 5B

Protein Summary
Description
Histone demethylase that demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code (PubMed:24952722, PubMed:27214403, PubMed:28262558). Does not demethylate histone H3 'Lys-9' or H3 'Lys-27'. Demethylates trimethylated, dimethylated and monomethylated H3 'Lys-4'. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5 (PubMed:24952722). In contrast, may act as a tumor suppressor for melanoma. Represses the CLOCK-ARNTL/BMAL1 heterodimer-mediated transcriptional activation of the core clock component PER2 (By similarity). This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367264
  • ENSP00000356233
  • ENSG00000117139
  • ENST00000367265
  • ENSP00000356234

Symbol
  • JARID1B
  • PLU1
  • RBBP2H1
  • CT31
  • PLU1
  • PUT1
  • MRT65
  • PLU-1
  • JARID1B
  • PPP1R98
  • RBP2-H1
  • RBBP2H1A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
disease perturbation
0.98
virus perturbation
0.98
transcription factor perturbation
0.94
molecular function
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.69   (req: < 5)
Gene RIFs: 66   (req: <= 3)
Antibodies: 350   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 245.69   (req: >= 5)
Gene RIFs: 66   (req: > 3)
Antibodies: 350   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 247
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (247)
CHEMBL3786952
Rendered image for CHEMBL3786952
2-(2-Aminothiazol-4-yl)isonicotinic Acid
Rendered image for 2-(2-Aminothiazol-4-yl)isonicotinic Acid
GSK-J1
Rendered image for GSK-J1
CHEMBL4216044
Rendered image for CHEMBL4216044
CHEMBL4287561
Rendered image for CHEMBL4287561
CHEMBL4287296
Rendered image for CHEMBL4287296
CHEMBL4281159
Rendered image for CHEMBL4281159
CHEMBL4289695
Rendered image for CHEMBL4289695
CHEMBL4283926
Rendered image for CHEMBL4283926
KDM5 inhibitor N71
Rendered image for KDM5 inhibitor N71
Protein-Protein Interactions (172)
FAM90A1
Tdark
Novelty:  0.95155075
p_int:  0.999998826
p_ni:  1.57e-7
p_wrong:  0.000001017
Score:  0.309
Data Source:  BioPlex,STRINGDB
TSPYL6
Tdark
Novelty:  0.68478376
p_int:  0.998065865
p_ni:  0.000001897
p_wrong:  0.001932239
Score:  0.221
Data Source:  BioPlex,STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.961
Data Source:  Reactome,STRINGDB
TFAP2C
Tbio
Family:  TF
Novelty:  0.00893737
Score:  0.945
Data Source:  Reactome,STRINGDB
CDKN1A
Tchem
Family:  Enzyme
Novelty:  0.00033009
Score:  0.915
Data Source:  STRINGDB
TFAP2A
Tbio
Family:  TF
Novelty:  0.00235655
Score:  0.9
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.888
Data Source:  STRINGDB
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
Score:  0.789
Data Source:  STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
Score:  0.775
Data Source:  STRINGDB
SETD1A
Tbio
Family:  Epigenetic
Novelty:  0.00248544
Score:  0.764
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
Gene expression (Transcription)
Generic Transcription Pathway
HDMs demethylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GDB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
1
1
0
5.7
17.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortical surface area measurement
0
5.7
17.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 5B
VGNC:8062
457630
Macaque
lysine demethylase 5B
706437
Mouse
MGI:1922855
75605
Rat
RGD:1565602
304809
Dog
lysine demethylase 5B
VGNC:42328
479999
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 5B
Macaque
lysine demethylase 5B
Mouse
Rat
Dog
lysine demethylase 5B
Publication Statistics
PubMed Score 245.69
PubMed score by year
PubTator Score 93.86
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title