You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
KDM5A
Lysine-specific demethylase 5A

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed:18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed:19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-ARNTL/BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399788
  • ENSP00000382688
  • ENSG00000073614

Symbol
  • JARID1A
  • RBBP2
  • RBP2
  • RBP2
  • RBBP2
  • RBBP-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
drug perturbation
0.96
transcription factor perturbation
0.94
molecular function
0.84
transcription factor binding site profile
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 115   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 222
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (222)
CHEMBL3786952
Rendered image for CHEMBL3786952
2,4-pyridine dicarboxylic acid
Rendered image for 2,4-pyridine dicarboxylic acid
GSK-J1
Rendered image for GSK-J1
CHEMBL4287561
Rendered image for CHEMBL4287561
CHEMBL4287296
Rendered image for CHEMBL4287296
CHEMBL4281159
Rendered image for CHEMBL4281159
CHEMBL4289695
Rendered image for CHEMBL4289695
CHEMBL4283926
Rendered image for CHEMBL4283926
KDM5 inhibitor N71
Rendered image for KDM5 inhibitor N71
PBIT
Rendered image for PBIT
Protein-Protein Interactions (162)
MORF4L1
Tbio
Family:  Epigenetic
Novelty:  0.01696001
p_int:  0.999999983
p_ni:  6e-9
p_wrong:  1.2e-8
Score:  0.91
Data Source:  BioPlex,STRINGDB
RBBP7
Tbio
Novelty:  0.01795364
p_int:  0.999999903
p_ni:  3.1e-8
p_wrong:  6.6e-8
Score:  0.857
Data Source:  BioPlex,STRINGDB
HDAC1
Tclin
Family:  Epigenetic
Novelty:  0.00065244
p_int:  0.999999518
p_ni:  4.82e-7
Score:  0.817
Data Source:  BioPlex,STRINGDB
SIN3B
Tbio
Novelty:  0.04097105
Score:  0.889
Data Source:  STRINGDB
GATAD1
Tbio
Family:  TF
Novelty:  0.0924778
Score:  0.866
Data Source:  STRINGDB
KDM6A
Tchem
Family:  Epigenetic
Novelty:  0.00267001
Score:  0.855
Data Source:  STRINGDB
KMT2A
Tchem
Family:  Epigenetic
Novelty:  0.00192554
Score:  0.85
Data Source:  STRINGDB
KDM1A
Tchem
Family:  Epigenetic
Novelty:  0.00142673
Score:  0.822
Data Source:  STRINGDB
PHF12
Tbio
Family:  Epigenetic
Novelty:  0.00240295
Score:  0.819
Data Source:  STRINGDB
KDM2B
Tchem
Family:  Epigenetic
Novelty:  0.01630517
Score:  0.767
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (29)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GDB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Mutant Phenotype (IMP)
CAFA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
9
6
8
9.4
96.7
alkaline phosphatase measurement
3
2
2
23.2
95.6
heel bone mineral density
3
3
4
94.5
blood metabolite measurement
2
3
3
91.9
sclerostin measurement
1
1
1
84
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
8
9.4
96.7
alkaline phosphatase measurement
2
23.2
95.6
heel bone mineral density
4
94.5
blood metabolite measurement
3
91.9
sclerostin measurement
1
84
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 5A
VGNC:8430
451737
Macaque
lysine demethylase 5A [Source:HGNC Symbol;Acc:HGNC:9886]
Mouse
MGI:2136980
214899
Dog
lysine demethylase 5A
VGNC:42327
477727
Horse
lysine demethylase 5A
VGNC:19339
100056935
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 5A
Macaque
lysine demethylase 5A [Source:HGNC Symbol;Acc:HGNC:9886]
Mouse
Dog
lysine demethylase 5A
Horse
lysine demethylase 5A
Publication Statistics
PubMed Score 115.00
PubMed score by year
PubTator Score 48.77
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title