KDM4D
Lysine-specific demethylase 4D
Protein Summary
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Demethylates both di- and trimethylated H3 'Lys-9' residue, while it has no activity on monomethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
- ENST00000335080
- ENSP00000334181
- ENSG00000186280
- ENST00000536741
- ENSP00000460897
- ENST00000610872
- ENSP00000482224
- JHDM3D
- JMJD2D
- JMJD2D
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.88 | ||
biological process | 0.55 | ||
tissue sample | 0.54 | ||
cell line | 0.52 | ||
cell type or tissue | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.37 (req: < 5)
Gene RIFs: 10 (req: <= 3)
Antibodies: 217 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 131.37 (req: >= 5)
Gene RIFs: 10 (req: > 3)
Antibodies: 217 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 13
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (13)
Protein-Protein Interactions (42)
TRPC4AP
Novelty: 0.02170224
p_int: 0.936359
p_wrong: 0.063641
Score: 0.313
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Chromatin modifying enzymes | ||||
Reactome | Chromatin organization | ||||
Reactome | HDMs demethylate histones | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Chromatin modifying enzymes | ||||
Chromatin organization | ||||
HDMs demethylate histones | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (10)
Components (6)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (1)
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1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 2 | 2 | 93.3 | |||||
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GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean platelet volume | 2 | 93.3 | |||||
Find similar targets by:
IDG Resources
Orthologs (5)
1 – 5 of 5
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | lysine demethylase 4D | VGNC:11861 | 466754 | |||||
Macaque | lysine-specific demethylase 4D | 698455 | ||||||
Mouse | MGI:3606484 | 244694 | ||||||
Rat | RGD:1591045 | 689582 | ||||||
Dog | lysine demethylase 4D | 485121 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | lysine demethylase 4D | |||||
Macaque | lysine-specific demethylase 4D | |||||
Mouse | ||||||
Rat | ||||||
Dog | lysine demethylase 4D | |||||
Publication Statistics
PubMed Score 131.37
PubMed score by year
PubTator Score 17.56
PubTator score by year
Related Publications
Text Mined References (21)
GeneRif Annotations (10)
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0 of 0
PMID | Year | Title |
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