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Tchem
KDM4B
Lysine-specific demethylase 4B

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27', H3 'Lys-36' nor H4 'Lys-20'. Only able to demethylate trimethylated H3 'Lys-9', with a weaker activity than KDM4A, KDM4C and KDM4D. Demethylation of Lys residue generates formaldehyde and succinate.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381759
  • ENSP00000371178
  • ENSG00000127663

Symbol
  • JHDM3B
  • JMJD2B
  • KIAA0876
  • JMJD2B
  • TDRD14B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.74
disease
0.64
transcription factor
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.84   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 505   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.84   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 505   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (70)
CHEMBL3786952
Rendered image for CHEMBL3786952
CHEMBL4216044
Rendered image for CHEMBL4216044
CHEMBL4438830
Rendered image for CHEMBL4438830
CHEMBL3774537
Rendered image for CHEMBL3774537
CHEMBL4567766
Rendered image for CHEMBL4567766
CHEMBL4447515
Rendered image for CHEMBL4447515
CHEMBL4585876
Rendered image for CHEMBL4585876
CHEMBL4449500
Rendered image for CHEMBL4449500
CHEMBL4525269
Rendered image for CHEMBL4525269
Protein-Protein Interactions (124)
ZNF414
Tdark
Novelty:  1.29024829
p_int:  0.999999646
p_ni:  3.52e-7
p_wrong:  2e-9
Score:  0.57
Data Source:  BioPlex,STRINGDB
KDM4A
Tchem
Family:  Epigenetic
Novelty:  0.00643043
p_int:  0.999896731
p_ni:  1.1e-8
p_wrong:  0.000103259
Score:  0.968
Data Source:  BioPlex,STRINGDB
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.994337329
p_ni:  0.005662671
Score:  0.669
Data Source:  BioPlex,STRINGDB
CCT4
Tbio
Novelty:  0.01176123
p_int:  0.986038659
p_ni:  0.013961341
Score:  0.288
Data Source:  BioPlex,STRINGDB
CCT6B
Tdark
Novelty:  0.28933315
p_int:  0.984717704
p_ni:  0.015282296
Data Source:  BioPlex
CCT2
Tbio
Novelty:  0.01967139
p_int:  0.975258414
p_ni:  0.024741586
Data Source:  BioPlex
CCT7
Tbio
Novelty:  0.02247038
p_int:  0.971735777
p_ni:  0.028264223
Score:  0.535
Data Source:  BioPlex,STRINGDB
CCDC85C
Tbio
Novelty:  0.30053883
p_int:  0.915476302
p_ni:  0.084521285
p_wrong:  0.000002413
Data Source:  BioPlex
CCT5
Tbio
Novelty:  0.02369118
p_int:  0.910593016
p_ni:  0.089406984
Score:  0.343
Data Source:  BioPlex,STRINGDB
TCP1
Tbio
Novelty:  0.00395241
p_int:  0.874844945
p_ni:  0.125155055
Score:  0.235
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
DNA Double Strand Break Response
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
DNA Double Strand Break Response
DNA Double-Strand Break Repair
DNA Repair
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (13)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
2
2
2
89.4
lymphocyte percentage of leukocytes
2
2
2
87.1
monocyte percentage of leukocytes
2
2
2
85.5
neutrophil count
2
2
2
79.6
systolic blood pressure
1
1
1
74.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil percentage of leukocytes
2
89.4
lymphocyte percentage of leukocytes
2
87.1
monocyte percentage of leukocytes
2
85.5
neutrophil count
2
79.6
systolic blood pressure
1
74.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 4B
VGNC:7573
455614
Macaque
lysine demethylase 4B
695760
Mouse
MGI:2442355
193796
Rat
RGD:1588576
301128
Dog
lysine demethylase 4B
VGNC:42325
476741
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 4B
Macaque
lysine demethylase 4B
Mouse
Rat
Dog
lysine demethylase 4B
Publication Statistics
PubMed Score 82.84
PubMed score by year
PubTator Score 37.79
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title