You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KDM3B
Lysine-specific demethylase 3B

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314358
  • ENSP00000326563
  • ENSG00000120733
  • ENST00000542866
  • ENSP00000439462

Symbol
  • C5orf7
  • JHDM2B
  • JMJD1B
  • KIAA1082
  • 5qNCA
  • NET22
  • C5orf7
  • JMJD1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.96
disease perturbation
0.83
transcription factor binding site profile
0.81
microRNA
0.75
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.52   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.52   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
TH
Tclin
Family:  Enzyme
Novelty:  0.00025719
p_int:  0.99999982
p_ni:  1.79e-7
p_wrong:  1e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
MRPL38
Tdark
Novelty:  0.71587283
p_int:  0.999982999
p_ni:  0.000017001
Data Source:  BioPlex
TRIM11
Tbio
Family:  Enzyme
Novelty:  0.02243955
p_int:  0.999949875
p_ni:  0.000050125
Data Source:  BioPlex
ALOX5
Tclin
Family:  Enzyme
Novelty:  0.00062988
p_int:  0.999916692
p_ni:  0.000083308
Data Source:  BioPlex
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.999908024
p_ni:  0.000091956
p_wrong:  2e-8
Data Source:  BioPlex
PLOD1
Tbio
Family:  Enzyme
Novelty:  0.00905345
p_int:  0.993798826
p_ni:  0.00620115
p_wrong:  2.4e-8
Score:  0.221
Data Source:  BioPlex,STRINGDB
RFPL4B
Tdark
Novelty:  2.42779597
p_int:  0.993066965
p_ni:  0.006933026
p_wrong:  9e-9
Data Source:  BioPlex
SERPINB2
Tbio
Novelty:  0.00204345
p_int:  0.990454225
p_ni:  0.009545752
p_wrong:  2.3e-8
Data Source:  BioPlex
SMYD3
Tchem
Family:  Epigenetic
Novelty:  0.01040802
p_int:  0.958719081
p_ni:  0.041009623
p_wrong:  0.000271295
Score:  0.617
Data Source:  BioPlex,STRINGDB
THRSP
Tbio
Novelty:  0.00938864
p_int:  0.882346458
p_ni:  0.096732657
p_wrong:  0.020920885
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (12)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
1
1
73.3
age at menarche
2
2
1
2.4
71.3
sex hormone-binding globulin measurement
4
1
4
66
7
5
2
1.1
62.8
testosterone measurement
2
2
2
59
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
IGF-1 measurement
1
73.3
age at menarche
1
2.4
71.3
sex hormone-binding globulin measurement
4
66
2
1.1
62.8
testosterone measurement
2
59
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 3B
VGNC:8625
462095
Macaque
lysine demethylase 3B
716648
Mouse
MGI:1923356
277250
Rat
RGD:1583423
682469
Dog
lysine demethylase 3B
VGNC:42323
474695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lysine demethylase 3B
Macaque
lysine demethylase 3B
Mouse
Rat
Dog
lysine demethylase 3B
Publication Statistics
PubMed Score 25.52
PubMed score by year
PubTator Score 10.11
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title