You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KDM3B
Lysine-specific demethylase 3B

Protein Summary
Description
Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314358
  • ENSP00000326563
  • ENSG00000120733
  • ENST00000542866
  • ENSP00000439462

Symbol
  • C5orf7
  • JHDM2B
  • JMJD1B
  • KIAA1082
  • 5qNCA
  • NET22
  • C5orf7
  • JMJD1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.96
disease perturbation
0.83
transcription factor binding site profile
0.81
microRNA
0.75
transcription factor
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.88   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 330   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 31.88   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0