Tchem KDM2B Lysine-specific demethylase 2B

Protein Summary

Description

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation. May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8NHM5
• A8MRS1
• Q1RLM7
• Q8NCI2
• Q96HC7
• Q96SL0
• Q96T03
• Q9NS96
• Q9UF75

Gene Name

• KDM2B

Ensembl ID

• ENST00000377069
• ENSP00000366269
• ENSG00000089094
• ENST00000377071
• ENSP00000366271
• ENST00000611216
• ENSP00000480847

Symbol

• CXXC2
• FBL10
• FBXL10
• JHDM1B
• PCCX2
• CXXC2
• Fbl10
• PCCX2
• FBXL10
• JHDM1B

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.88
transcription factor binding site profile	0.87
protein domain	0.85
kinase perturbation	0.81
transcription factor	0.77

Protein Classes

DTO Classes

Protein / Epigenetic Regulator / Eraser / Lysine Demethylase / Jumonji Domain-containing / Lysine-specific Demethylase 2b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.77   (req: < 5)

Gene RIFs: 53   (req: <= 3)

Antibodies: 299   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.77   (req: >= 5)

Gene RIFs: 53   (req: > 3)

Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 92

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0