Tbio KDELR2 ER lumen protein-retaining receptor 2

Protein Summary

Description

Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi. This receptor recognizes K-D-E-L. Retention of resident soluble proteins in the lumen of the endoplasmic reticulum (ER) is achieved in both yeast and animal cells by their continual retrieval from the cis-Golgi, or a pre-Golgi compartment. Sorting of these proteins is dependent on a C-terminal tetrapeptide signal, usually lys-asp-glu-leu (KDEL) in animal cells, and his-asp-glu-leu (HDEL) in S. cerevisiae. This process is mediated by a receptor that recognizes, and binds the tetrapeptide-containing protein, and returns it to the ER. In yeast, the sorting receptor encoded by a single gene, ERD2, is a seven-transmembrane protein. Unlike yeast, several human homologs of the ERD2 gene, constituting the KDEL receptor gene family, have been described. KDELR2 was the second member of the family to be identified, and it encodes a protein which is 83% identical to the KDELR1 gene product. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P33947
• A4D2P4
• Q6IPC5
• Q96E30

Gene Name

• KDELR2

Ensembl ID

• ENST00000258739
• ENSP00000258739
• ENSG00000136240
• ENST00000490996
• ENSP00000420501

Symbol

• ERD2.2
• ELP-1
• ERD2.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
virus perturbation	0.98
transcription factor perturbation	0.8
small molecule perturbation	0.77

Protein Classes

PANTHER Classes

Protein / Receptor / Er Lumen Protein-retaining Receptor 2

Protein / Membrane Traffic Protein / Membrane Trafficking Regulatory Protein / Er Lumen Protein-retaining Receptor 2

DTO Classes

Protein / Transporter / Membrane Trafficking Regulatory Protein / Er Lumen Protein-retaining Receptor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.87   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 162   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.87   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0