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Tbio
KDELC1
KDEL motif-containing protein 1

Protein Summary
Description
This gene encodes a protein product localized to the lumen of the endoplasmic reticulum. As a member of the endoplasmic reticulum protein family the encoded protein contains a Lys-Asp-Glu-Leu or KDEL motif located at the extreme C-terminus which prevents all endoplasmic reticulum resident proteins from being secreted. Proteins carrying this motif are bound by a receptor in the Golgi apparatus so that the receptor-ligand complex returns to the endoplasmic reticulum. A processed non-transcribed pseudogene located in an intron of a sodium transporter gene on chromosome 5 has been defined for this gene. This gene has multiple transcript variants which are predicted to encode distinct isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376004
  • ENSP00000365172
  • ENSG00000134901

Symbol
  • EP58
  • EP58
  • ERp58
  • KDEL1
  • KDELC1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
virus perturbation
0.72
transcription factor binding site profile
0.66
tissue
0.63
kinase perturbation
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 130   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
SPSB3
Tdark
Novelty:  0.07215887
p_int:  0.999889508
p_ni:  0.000099974
p_wrong:  0.000010519
Data Source:  BioPlex
TAZ
Tbio
Novelty:  0.00372301
p_int:  0.945129875
p_ni:  0.054870125
Score:  0.204
Data Source:  BioPlex,STRINGDB
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.944618744
p_ni:  0.055381256
Data Source:  BioPlex
TRIM65
Tbio
Novelty:  0.09830696
p_int:  0.909876727
p_ni:  0.048571803
p_wrong:  0.041551471
Data Source:  BioPlex
CALCOCO2
Tbio
Novelty:  0.01456844
p_int:  0.894901548
p_ni:  0.105089286
p_wrong:  0.000009165
Data Source:  BioPlex
LCN6
Tbio
Novelty:  0.11406686
p_int:  0.89451671
p_ni:  0.10548329
Data Source:  BioPlex
LOXL3
Tchem
Family:  Enzyme
Novelty:  0.03895154
p_int:  0.763947398
p_ni:  0.236052602
Score:  0.252
Data Source:  BioPlex,STRINGDB
FLNA
Tbio
Novelty:  0.00156479
Score:  0.756
Data Source:  STRINGDB
BIVM
Tdark
Novelty:  0.57082952
Score:  0.692
Data Source:  STRINGDB
NAALAD2
Tchem
Family:  Enzyme
Novelty:  0.18444329
Score:  0.602
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KDEL motif containing 1
VGNC:7292
467315
Mouse
MGI:1919300
72050
Dog
KDEL motif containing 1
VGNC:42313
100855922
Horse
KDEL motif containing 1
VGNC:19328
100051191
Cow
KDEL motif containing 1
VGNC:30517
514810
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KDEL motif containing 1
Mouse
Dog
KDEL motif containing 1
Horse
KDEL motif containing 1
Cow
KDEL motif containing 1
Publication Statistics
PubMed Score 10.30
PubMed score by year
PubTator Score 3.46
PubTator score by year
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Related Publications
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PMID
Year
Title