You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KCTD9
BTB/POZ domain-containing protein KCTD9

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination of target proteins, leading to their degradation by the proteasome.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000221200
  • ENSP00000221200
  • ENSG00000104756

Symbol
  • BTBD27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
kinase perturbation
0.76
histone modification site profile
0.74
protein domain
0.73
tissue sample
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.37   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 193   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.37   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 193   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (30)
RCCD1
Tbio
Novelty:  0.07481641
p_int:  0.999999999
p_ni:  1e-9
Score:  0.159
Data Source:  BioPlex,STRINGDB
NRP1
Tchem
Novelty:  0.00153628
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.175
Data Source:  BioPlex,STRINGDB
NOL9
Tdark
Family:  Enzyme
Novelty:  0.05830272
p_int:  0.999977739
p_ni:  0.000022261
Score:  0.189
Data Source:  BioPlex,STRINGDB
HOXB6
Tbio
Family:  TF
Novelty:  0.0176813
p_int:  0.999815986
p_ni:  0.000184013
Data Source:  BioPlex
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.999145802
p_ni:  0.000854178
p_wrong:  2e-8
Data Source:  BioPlex
NUP35
Tbio
Novelty:  0.0355102
p_int:  0.998787041
p_ni:  0.001212944
p_wrong:  1.5e-8
Score:  0.261
Data Source:  BioPlex,STRINGDB
ATXN7L1
Tdark
Novelty:  0.43694835
p_int:  0.998771011
p_ni:  0.001228784
p_wrong:  2.04e-7
Data Source:  BioPlex
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.996279815
p_ni:  0.003720185
Score:  0.549
Data Source:  BioPlex,STRINGDB
SLC30A9
Tbio
Family:  Transporter
Novelty:  0.07156604
Score:  0.767
Data Source:  STRINGDB
MSANTD3
Tdark
Novelty:  0.61023843
Score:  0.752
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
3
3
82.9
heel bone mineral density
2
2
2
76.7
reticulocyte measurement
3
2
3
70.4
testosterone measurement
2
2
2
66.6
lymphocyte count
2
1
2
64.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
82.9
heel bone mineral density
2
76.7
reticulocyte measurement
3
70.4
testosterone measurement
2
66.6
lymphocyte count
2
64.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 9
744067
Macaque
potassium channel tetramerization domain containing 9
711515
Mouse
MGI:2145579
105440
Rat
RGD:1312010
364410
Dog
potassium channel tetramerization domain containing 9
VGNC:42312
486109
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 9
Macaque
potassium channel tetramerization domain containing 9
Mouse
Rat
Dog
potassium channel tetramerization domain containing 9
Publication Statistics
PubMed Score 5.37
PubMed score by year
PubTator Score 3.21
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title