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Tbio
KCTD6
BTB/POZ domain-containing protein KCTD6

Protein Summary
Description
Probable substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex mediating the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes the ubiquitination of HDAC1; the function seems to depend on KCTD11:KCTD6 oligomerization. Can function as antagonist of the Hedgehog pathway by affecting the nuclear transfer of transcription factor GLI1; the function probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. Inhibits cell growth and tumorigenicity of medulloblastoma (MDB) (PubMed:21472142). Involved in regulating protein levels of ANK1 isoform Mu17 probably implicating CUL3-dependent proteasomal degradation (PubMed:22573887).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355076
  • ENSP00000347188
  • ENSG00000168301
  • ENST00000404589
  • ENSP00000384948
  • ENST00000490264
  • ENSP00000417490

Symbol
  • KCASH3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.72
kinase perturbation
0.71
tissue sample
0.68
transcription factor
0.67
histone modification site profile
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.73   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 141   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.73   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 141   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (325)
UBE2M
Tchem
Novelty:  0.02353106
p_int:  0.999990684
p_ni:  0.000009125
p_wrong:  1.91e-7
Score:  0.914
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.999956771
p_ni:  0.000043126
p_wrong:  1.03e-7
Score:  0.973
Data Source:  BioPlex,STRINGDB
IFIT5
Tbio
Novelty:  0.03547542
p_int:  0.999867475
p_ni:  0.000132517
p_wrong:  8e-9
Score:  0.336
Data Source:  BioPlex,STRINGDB
FSD2
Tbio
Novelty:  0.1302271
p_int:  0.999840682
p_ni:  0.000159025
p_wrong:  2.92e-7
Data Source:  BioPlex
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999367413
p_ni:  0.00025422
p_wrong:  0.000378367
Score:  0.909
Data Source:  BioPlex,STRINGDB
ZFYVE1
Tbio
Novelty:  0.00372406
p_int:  0.998996994
p_ni:  0.000797059
p_wrong:  0.000205947
Score:  0.332
Data Source:  BioPlex,STRINGDB
FUS
Tbio
Novelty:  0.00065625
p_int:  0.998283177
p_ni:  0.001513672
p_wrong:  0.000203151
Score:  0.197
Data Source:  BioPlex,STRINGDB
CTSE
Tchem
Family:  Enzyme
Novelty:  0.00432129
p_int:  0.986614278
p_ni:  0.003787624
p_wrong:  0.009598098
Score:  0.254
Data Source:  BioPlex,STRINGDB
CUL7
Tbio
Novelty:  0.02183958
Score:  0.939
Data Source:  STRINGDB
KLHL41
Tbio
Novelty:  0.03973182
Score:  0.934
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
ESR-mediated signaling
Estrogen-dependent gene expression
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
3
3
92.6
hemoglobin measurement
3
3
3
89.1
low density lipoprotein cholesterol measurement
4
5
5
88.2
aspartate aminotransferase measurement
2
2
1
13.3
85.7
2
2
0
1.1
61.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
92.6
hemoglobin measurement
3
89.1
low density lipoprotein cholesterol measurement
5
88.2
aspartate aminotransferase measurement
1
13.3
85.7
0
1.1
61.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 6
VGNC:11420
470833
Macaque
potassium channel tetramerization domain containing 6
701810
Mouse
MGI:1918643
71393
Rat
RGD:1308208
305792
Dog
potassium channel tetramerization domain containing 6
VGNC:42310
100855620
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 6
Macaque
potassium channel tetramerization domain containing 6
Mouse
Rat
Dog
potassium channel tetramerization domain containing 6
Publication Statistics
PubMed Score 1.73
PubMed score by year
PubTator Score 2.24
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title