Tbio KCTD5 BTB/POZ domain-containing protein KCTD5

Protein Summary

Description

Its interaction with CUL3 suggests that it may act as a substrate adapter in some E3 ligase complex. Does not affect the function of Kv channel Kv2.1/KCNB1, Kv1.2/KCNA2, Kv4.2/KCND2 and Kv3.4/KCNC4.

Uniprot Accession IDs

• Q9NXV2
• D3DU96

Gene Name

• KCTD5

Ensembl ID

• ENST00000301738
• ENSP00000301738
• ENSG00000167977

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.91
transcription factor binding site profile	0.85
histone modification site profile	0.81
virus perturbation	0.76
transcription factor	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.45   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 83   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.45   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (43)

Explore Interacting Targets

1 – 10 of 43

• See Interactions on String-DB

KCTD17

Tbio

Novelty:  0.12105733

p_int:  0.999987226

p_ni:  0.000012774

Score:  0.828

Data Source:  BioPlex,STRINGDB

PDZK1P1

Tdark

p_int:  0.999688811

p_ni:  0.000311189

Data Source:  BioPlex

SLC9A3R2

Tbio

Family:  Transporter

Novelty:  0.01401705

p_int:  0.998870998

p_ni:  0.001129002

Score:  0.208

Data Source:  BioPlex,STRINGDB

GNG2

Tbio

Novelty:  0.04807242

p_int:  0.811108887

p_ni:  0.18888768

p_wrong:  0.000003432

Data Source:  BioPlex

KCND2

Tclin

Family:  IC

Novelty:  0.00297203

p_int:  0.798166348

p_ni:  0.20183353

p_wrong:  1.22e-7

Score:  0.871

Data Source:  BioPlex,STRINGDB

CUL3

Tbio

Novelty:  0.0028737

Score:  0.857

Data Source:  STRINGDB

PDZK1

Tbio

Novelty:  0.01129974

Score:  0.8

Data Source:  STRINGDB

KCTD11

Tchem

Novelty:  0.11239142

Score:  0.715

Data Source:  STRINGDB

GORASP2

Tbio

Novelty:  0.02121907

Score:  0.662

Data Source:  STRINGDB

KCTD20

Tdark

Novelty:  0.47655751

Score:  0.661

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (0)

No pathways found

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (10)

Functions (3)

Components (4)

Processes (3)

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1 – 3 of 3

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Direct Assay (IDA)	MGI
identical protein binding	Inferred from Physical Interaction (IPI)	IntAct
cullin family protein binding	Inferred from Biological aspect of Ancestor (IBA)	GO_Central

Disease Associations ()

No disease associations found

GWAS Traits (9)

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5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	3	3	3		93.4
eosinophil percentage of leukocytes	EFO_0007991	2	2	2		87.5
intraocular pressure measurement	EFO_0004695	1	1	0	8.7	70.2
body height	EFO_0004339	1	1	1		65.5
eosinophil percentage of granulocytes	EFO_0007996	1	1	1		59.6

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
eosinophil count	EFO_0004842	3		93.4
eosinophil percentage of leukocytes	EFO_0007991	2		87.5
intraocular pressure measurement	EFO_0004695	0	8.7	70.2
body height	EFO_0004339	1		65.5
eosinophil percentage of granulocytes	EFO_0007996	1		59.6

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Complete proteome
Cytoplasm
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
BMI-adjusted hip circumference
body height
body mass index
eosinophil count
eosinophil percentage of granulocytes
eosinophil percentage of leukocytes
intraocular pressure measurement
neutrophil percentage of granulocytes
sum of eosinophil and basophil counts

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	potassium channel tetramerization domain containing 5	VGNC:13724	453840
Mouse	potassium channel tetramerisation domain containing 5	MGI:1916509	69259
Rat	potassium channel tetramerization domain containing 5	RGD:1304990	287109
Dog	potassium channel tetramerization domain containing 5	VGNC:42309	490058
Cow	potassium channel tetramerization domain containing 5	VGNC:30513	100125308

Species	Name	OMA	EggNOG	Inparanoid
Chimp	potassium channel tetramerization domain containing 5
Mouse	potassium channel tetramerisation domain containing 5
Rat	potassium channel tetramerization domain containing 5
Dog	potassium channel tetramerization domain containing 5
Cow	potassium channel tetramerization domain containing 5

Publication Statistics

PubMed Score 13.45

PubMed score by year

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PubTator Score 6.56

PubTator score by year

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Related Publications

Text Mined References (14)

GeneRif Annotations (5)

Items per page:

10

0 of 0

PMID	Year	Title