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Tdark
KCTD3
BTB/POZ domain-containing protein KCTD3

Protein Summary
Description
Accessory subunit of potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) upregulating its cell-surface expression and current density without affecting its voltage dependence and kinetics. This gene encodes a member of the potassium channel tetramerization-domain containing (KCTD) protein family. Members of this protein family regulate the biophysical characteristics of ion channels. In mouse, this protein interacts with hyperpolarization-activated cyclic nucleotide-gated channel complex 3 and enhances its cell surface expression and current density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
virus perturbation
0.83
transcription factor binding site profile
0.75
histone modification site profile
0.71
protein complex
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.62   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (68)
KCTD15
Tbio
Novelty:  0.05277304
p_int:  0.999999986
p_ni:  1.2e-8
p_wrong:  3e-9
Score:  0.273
Data Source:  BioPlex,STRINGDB
SHKBP1
Tbio
Novelty:  0.00235279
p_int:  0.999999983
p_ni:  1.8e-8
Score:  0.825
Data Source:  BioPlex,STRINGDB
FHL3
Tbio
Novelty:  0.11505924
p_int:  0.999999838
p_ni:  1.62e-7
Data Source:  BioPlex
FBLIM1
Tbio
Novelty:  0.0332985
p_int:  0.999999645
p_ni:  3.56e-7
Data Source:  BioPlex
KCTD1
Tbio
Novelty:  0.09964774
p_int:  0.999999137
p_ni:  7e-9
p_wrong:  8.56e-7
Score:  0.377
Data Source:  BioPlex,STRINGDB
PDZK1P1
Tdark
p_int:  0.999999065
p_ni:  9.35e-7
Data Source:  BioPlex
WDR83
Tbio
Novelty:  0.11602568
p_int:  0.999997807
p_ni:  0.000002193
Data Source:  BioPlex
ASPSCR1
Tbio
Novelty:  0.01172319
p_int:  0.999997172
p_ni:  0.000002828
Score:  0.189
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999877652
p_ni:  0.000122348
Data Source:  BioPlex
SNX27
Tbio
Novelty:  0.02419724
p_int:  0.999405855
p_ni:  0.000594143
p_wrong:  2e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
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GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 3
VGNC:1284
457735
Macaque
potassium channel tetramerization domain containing 3
708471
Mouse
MGI:2444629
226823
Rat
RGD:1310658
305055
Dog
potassium channel tetramerization domain containing 3
VGNC:42307
478960
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 3
Macaque
potassium channel tetramerization domain containing 3
Mouse
Rat
Dog
potassium channel tetramerization domain containing 3
Publication Statistics
PubMed Score 2.62
PubMed score by year
PubTator Score 2.68
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title