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Tdark
KCTD2
BTB/POZ domain-containing protein KCTD2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322444
  • ENSP00000312814
  • ENSG00000180901

Symbol
  • KIAA0176
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.95
transcription factor perturbation
0.91
disease perturbation
0.79
histone modification site profile
0.78
transcription factor
0.72


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.75   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 65   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.75   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 65   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (49)
KCTD17
Tbio
Novelty:  0.12105733
p_int:  0.999999033
p_ni:  1.68e-7
p_wrong:  7.99e-7
Score:  0.744
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999998269
p_ni:  0.000001727
p_wrong:  4e-9
Data Source:  BioPlex
PDZK1P1
Tdark
p_int:  0.999995194
p_ni:  0.000004508
p_wrong:  2.98e-7
Data Source:  BioPlex
RGS3
Tbio
Novelty:  0.01749541
p_int:  0.9998864
p_ni:  0.000113513
p_wrong:  8.7e-8
Data Source:  BioPlex
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.999863403
p_ni:  0.000136533
p_wrong:  6.4e-8
Data Source:  BioPlex
REPIN1
Tbio
Family:  TF
Novelty:  0.01152362
p_int:  0.998388442
p_ni:  0.001611205
p_wrong:  3.53e-7
Score:  0.537
Data Source:  BioPlex,STRINGDB
TMEM255A
Tdark
Novelty:  1.03700118
p_int:  0.998127649
p_ni:  0.001857378
p_wrong:  0.000014973
Score:  0.234
Data Source:  BioPlex,STRINGDB
TNFSF14
Tbio
Novelty:  0.01370893
p_int:  0.99434193
p_ni:  0.00157746
p_wrong:  0.004080609
Data Source:  BioPlex
GLRA3
Tchem
Family:  IC
Novelty:  0.0209653
p_int:  0.982674931
p_ni:  0.017309382
p_wrong:  0.000015687
Score:  0.39
Data Source:  BioPlex,STRINGDB
ARRDC1
Tbio
Novelty:  0.10481621
p_int:  0.980631309
p_ni:  0.000793548
p_wrong:  0.018575142
Score:  0.607
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
1
4
80.9
lymphocyte count
1
1
1
66.3
ferritin measurement
1
1
1
55.2
lymphocyte percentage of leukocytes
2
2
2
55.2
C-reactive protein measurement
1
1
1
46.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
80.9
lymphocyte count
1
66.3
ferritin measurement
1
55.2
lymphocyte percentage of leukocytes
2
55.2
C-reactive protein measurement
1
46.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 2
VGNC:12333
736423
Macaque
potassium channel tetramerization domain containing 2
700474
Mouse
MGI:1917632
70382
Dog
potassium channel tetramerization domain containing 2
VGNC:42305
609652
Horse
potassium channel tetramerization domain containing 2
VGNC:19323
100060086
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 2
Macaque
potassium channel tetramerization domain containing 2
Mouse
Dog
potassium channel tetramerization domain containing 2
Horse
potassium channel tetramerization domain containing 2
Publication Statistics
PubMed Score 2.75
PubMed score by year
PubTator Score 2.17
PubTator score by year
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Related Publications
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PMID
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