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Tbio
KCTD17
BTB/POZ domain-containing protein KCTD17

Protein Summary
Description
Is a positive regulator of ciliogenesis, playing a crucial role in the initial steps of axoneme extension. It acts as a substrate-adapter for CUL3-RING ubiquitin ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of TCHP, a protein involved in ciliogenesis down-regulation (PubMed:25270598). May be involved in endoplasmic reticulum calcium ion homeostasis (PubMed:25983243). This gene encodes a protein that belongs to a conserved family of potassium channel tetramerization domain (KCTD)-containing proteins. The encoded protein functions in ciliogenesis by acting as a substrate adaptor for the cullin3-based ubiquitin-conjugating enzyme E3 ligase, and targets trichoplein, a keratin-binding protein, for degradation via polyubiquitinylation. A mutation in this gene is associated with autosomal dominant myoclonic dystonia 26. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402077
  • ENSP00000384391
  • ENSG00000100379
  • ENST00000403888
  • ENSP00000385096
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.79
histone modification site profile
0.66
tissue sample
0.65
cellular component
0.6
small molecule perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 98   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.95   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 98   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (71)
POLK
Tbio
Family:  Enzyme
Novelty:  0.01378154
p_int:  0.999999884
p_ni:  9.8e-8
p_wrong:  1.8e-8
Score:  0.169
Data Source:  BioPlex,STRINGDB
KCTD2
Tdark
Novelty:  0.42992811
p_int:  0.999999033
p_ni:  1.68e-7
p_wrong:  7.99e-7
Score:  0.744
Data Source:  BioPlex,STRINGDB
PDZK1P1
Tdark
p_int:  0.999998463
p_ni:  0.000001537
Data Source:  BioPlex
ZMYND8
Tbio
Family:  Epigenetic
Novelty:  0.05352096
p_int:  0.99999802
p_ni:  0.00000198
Data Source:  BioPlex
KCTD5
Tbio
Novelty:  0.07740057
p_int:  0.999987226
p_ni:  0.000012774
Score:  0.828
Data Source:  BioPlex,STRINGDB
SLC9A3R2
Tbio
Family:  Transporter
Novelty:  0.01401705
p_int:  0.999924874
p_ni:  0.000075126
Score:  0.155
Data Source:  BioPlex,STRINGDB
POLRMT
Tbio
Family:  Enzyme
Novelty:  0.01398067
p_int:  0.999909945
p_ni:  0.000090055
Score:  0.171
Data Source:  BioPlex,STRINGDB
ZNF687
Tbio
Family:  TF
Novelty:  0.14707532
p_int:  0.999890439
p_ni:  0.000109561
Data Source:  BioPlex
CDC42BPA
Tchem
Family:  Kinase
Novelty:  0.02575412
p_int:  0.999885558
p_ni:  0.000114436
p_wrong:  7e-9
Data Source:  BioPlex
THAP9
Tbio
Family:  TF
Novelty:  0.25915023
p_int:  0.999843399
p_ni:  1.2e-8
p_wrong:  0.00015659
Score:  0.212
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
8
12
17
99.9
hemoglobin measurement
15
8
18
99.7
mean corpuscular volume
10
5
12
98.8
HbA1c measurement
8
9
14
98.7
mean corpuscular hemoglobin concentration
12
4
12
98.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
17
99.9
hemoglobin measurement
18
99.7
mean corpuscular volume
12
98.8
HbA1c measurement
14
98.7
mean corpuscular hemoglobin concentration
12
98.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 17
VGNC:5273
458804
Macaque
potassium channel tetramerization domain containing 17
696210
Mouse
MGI:1920094
72844
Rat
RGD:1311154
300317
Dog
potassium channel tetramerization domain containing 17
VGNC:54152
481274
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 17
Macaque
potassium channel tetramerization domain containing 17
Mouse
Rat
Dog
potassium channel tetramerization domain containing 17
Publication Statistics
PubMed Score 6.95
PubMed score by year
PubTator Score 3.56
PubTator score by year
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Related Publications
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PMID
Year
Title