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Tbio
KCTD16
BTB/POZ domain-containing protein KCTD16

Protein Summary
Description
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000507359
  • ENSP00000426548
  • ENSG00000183775
  • ENST00000512467
  • ENSP00000424151

Symbol
  • KIAA1317
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.85
cell line
0.67
gene perturbation
0.62
virus perturbation
0.59
transcription factor binding site profile
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.91   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 72   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.91   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 72   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.99997875
p_ni:  0.000007733
p_wrong:  0.000013517
Data Source:  BioPlex
KCTD12
Tchem
Novelty:  0.0386637
p_int:  0.999958312
p_ni:  6.3e-8
p_wrong:  0.000041625
Data Source:  BioPlex
HAL
Tbio
Family:  Enzyme
Novelty:  0.01504631
p_int:  0.981685688
p_ni:  0.0040506
p_wrong:  0.014263711
Score:  0.342
Data Source:  BioPlex,STRINGDB
TMEM236
Tdark
Novelty:  2.30662044
Score:  0.715
Data Source:  STRINGDB
KCTD20
Tdark
Novelty:  0.47655751
Score:  0.599
Data Source:  STRINGDB
NKAIN3
Tdark
Family:  Enzyme
Novelty:  0.3456674
Score:  0.584
Data Source:  STRINGDB
CFAP52
Tbio
Novelty:  0.23267809
Score:  0.581
Data Source:  STRINGDB
PLAC8L1
Tdark
Novelty:  2.10744169
Score:  0.577
Data Source:  STRINGDB
SNCB
Tbio
Novelty:  0.00743454
Score:  0.574
Data Source:  STRINGDB
PLEKHA2
Tbio
Novelty:  0.14583759
Score:  0.573
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
1
1
61.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
daytime rest measurement
1
61.4
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 16
VGNC:13525
471683
Macaque
potassium channel tetramerization domain containing 16
706542
Mouse
MGI:1914659
383348
Dog
potassium channel tetramerization domain containing 16
VGNC:52140
487196
Cow
potassium channel tetramerization domain containing 16
VGNC:30505
527830
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 16
Macaque
potassium channel tetramerization domain containing 16
Mouse
Dog
potassium channel tetramerization domain containing 16
Cow
potassium channel tetramerization domain containing 16
Publication Statistics
PubMed Score 10.91
PubMed score by year
PubTator Score 1.44
PubTator score by year
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Related Publications
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PMID
Year
Title