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Tdark
KCTD14
BTB/POZ domain-containing protein KCTD14

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353172
  • ENSP00000316482
  • ENSG00000151364
  • ENST00000533144
  • ENSP00000431155
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
microRNA
0.61
virus perturbation
0.55
histone modification site profile
0.47
gene perturbation
0.46


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.92   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.92   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (18)
ACSF3
Tbio
Family:  Enzyme
Novelty:  0.04255285
p_int:  0.931690408
p_ni:  0.06830959
p_wrong:  2e-9
Score:  0.622
Data Source:  BioPlex,STRINGDB
AAMDC
Tdark
Novelty:  0.12623938
Score:  0.688
Data Source:  STRINGDB
USP35
Tbio
Family:  Enzyme
Novelty:  0.09341335
Score:  0.668
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.569
Data Source:  STRINGDB
ALG8
Tbio
Family:  Enzyme
Novelty:  0.03721075
Score:  0.563
Data Source:  STRINGDB
INTS4
Tdark
Novelty:  0.20868831
Score:  0.554
Data Source:  STRINGDB
NARS2
Tbio
Family:  Enzyme
Novelty:  0.01879317
Score:  0.549
Data Source:  STRINGDB
C11orf45
Tdark
Novelty:  2.57451168
Score:  0.54
Data Source:  STRINGDB
TMEM184A
Tbio
Novelty:  0.16408207
Score:  0.532
Data Source:  STRINGDB
CLNS1A
Tbio
Novelty:  0.01824362
Score:  0.508
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
33.1
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 14
VGNC:1081
100608161
Mouse
MGI:1289222
233529
Rat
RGD:1306430
308836
Dog
potassium channel tetramerization domain containing 14
VGNC:52262
485170
Horse
potassium channel tetramerization domain containing 14
VGNC:19319
100063019
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 14
Mouse
Rat
Dog
potassium channel tetramerization domain containing 14
Horse
potassium channel tetramerization domain containing 14
Publication Statistics
PubMed Score 0.92
PubMed score by year
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Related Publications
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PMID
Year
Title