You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
KCTD13
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

Protein Summary
Description
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308768
  • ENSP00000311202
  • ENSG00000174943
  • ENST00000568000
  • ENSP00000455785

Symbol
  • BACURD1
  • PDIP1
  • POLDIP1
  • PDIP1
  • FKSG86
  • BACURD1
  • POLDIP1
  • hBACURD1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
biological process
0.79
tissue sample
0.65
transcription factor binding site profile
0.63
kinase perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.97   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.97   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (61)
TNFAIP1
Tbio
Novelty:  0.04006419
p_int:  0.99999991
p_ni:  9e-8
Score:  0.861
Data Source:  BioPlex,STRINGDB
LSM3
Tbio
Novelty:  0.05044984
p_int:  0.999999856
p_ni:  1e-7
p_wrong:  4.4e-8
Data Source:  BioPlex
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.999982165
p_ni:  0.000017789
p_wrong:  4.6e-8
Score:  0.221
Data Source:  BioPlex,STRINGDB
CUL3
Tbio
Novelty:  0.0028737
p_int:  0.99997383
p_ni:  0.00002617
Score:  0.811
Data Source:  BioPlex,STRINGDB
KCTD10
Tbio
Novelty:  0.10573929
p_int:  0.999966488
p_ni:  0.000033512
Score:  0.84
Data Source:  BioPlex,STRINGDB
USP25
Tchem
Family:  Enzyme
Novelty:  0.03671706
p_int:  0.999793371
p_ni:  0.000206532
p_wrong:  9.7e-8
Score:  0.812
Data Source:  BioPlex,STRINGDB
FLNC
Tbio
Novelty:  0.00463205
p_int:  0.96546384
p_ni:  0.03453616
Score:  0.759
Data Source:  BioPlex,STRINGDB
HSPB8
Tbio
Novelty:  0.00298618
p_int:  0.801594229
p_ni:  0.000167597
p_wrong:  0.198238173
Score:  0.381
Data Source:  BioPlex,STRINGDB
PFDN2
Tbio
Novelty:  0.08537716
p_int:  0.763660898
p_ni:  0.236339102
Score:  0.179
Data Source:  BioPlex,STRINGDB
POLD2
Tbio
Family:  Enzyme
Novelty:  0.05932998
Score:  0.853
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
5
6
96.4
waist-hip ratio
3
3
3
89.1
appendicular lean mass
2
1
2
82.7
body height
1
1
1
78
visceral adipose tissue measurement
1
1
1
77.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
96.4
waist-hip ratio
3
89.1
appendicular lean mass
2
82.7
body height
1
78
visceral adipose tissue measurement
1
77.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 13
VGNC:8983
454030
Mouse
MGI:1923739
233877
Rat
RGD:735189
293497
Dog
potassium channel tetramerization domain containing 13
VGNC:42302
489942
Horse
potassium channel tetramerization domain containing 13
VGNC:19318
100065972
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 13
Mouse
Rat
Dog
potassium channel tetramerization domain containing 13
Horse
potassium channel tetramerization domain containing 13
Publication Statistics
PubMed Score 17.97
PubMed score by year
PubTator Score 5.72
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title