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Tchem
KCTD12
BTB/POZ domain-containing protein KCTD12

Protein Summary
Description
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377474
  • ENSP00000366694
  • ENSG00000178695

Symbol
  • C13orf2
  • KIAA1778
  • PFET1
  • PFET1
  • PFETIN
  • C13orf2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
interacting protein
0.93
PubMedID
0.9
cell type or tissue
0.86
microRNA
0.79


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.85   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.85   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 23
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (51)
P0CG12
Tdark
Novelty:  0.15007488
p_int:  0.999998982
p_ni:  0.000001017
p_wrong:  1e-9
Data Source:  BioPlex
PIF1
Tbio
Family:  Enzyme
Novelty:  0.00449506
p_int:  0.999998546
p_ni:  0.000001426
p_wrong:  2.8e-8
Data Source:  BioPlex
ARHGEF39
Tdark
Novelty:  0.30447134
p_int:  0.99999732
p_ni:  0.000002667
p_wrong:  1.3e-8
Data Source:  BioPlex
KCTD16
Tbio
Novelty:  0.09898256
p_int:  0.999958312
p_ni:  6.3e-8
p_wrong:  0.000041625
Data Source:  BioPlex
PUSL1
Tdark
Family:  Enzyme
Novelty:  2.39739964
p_int:  0.999943906
p_ni:  0.000056091
p_wrong:  4e-9
Data Source:  BioPlex
ZIC2
Tbio
Family:  TF
Novelty:  0.00900257
p_int:  0.99987167
p_ni:  0.00007549
p_wrong:  0.00005284
Data Source:  BioPlex
GTF2F1
Tbio
Novelty:  0.02118098
p_int:  0.998508642
p_ni:  0.001491358
Data Source:  BioPlex
ENDOG
Tbio
Family:  Enzyme
Novelty:  0.00404275
p_int:  0.997653194
p_ni:  0.00233799
p_wrong:  0.000008816
Data Source:  BioPlex
GNG2
Tbio
Novelty:  0.04807242
p_int:  0.99710291
p_ni:  0.00289709
Data Source:  BioPlex
DNAH14
Tdark
Novelty:  0.28289652
p_int:  0.996504648
p_ni:  0.003370586
p_wrong:  0.000124766
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
potassium channel tetramerization domain containing 12 [Source:HGNC Symbol;Acc:HGNC:14678]
Mouse
MGI:2145823
239217
Dog
potassium channel tetramerization domain containing 12
VGNC:42301
485495
Cow
potassium channel tetramerization domain containing 12
VGNC:30502
616416
Opossum
potassium channel tetramerization domain containing 12
100010822
Species
Name
OMA
EggNOG
Inparanoid
Macaque
potassium channel tetramerization domain containing 12 [Source:HGNC Symbol;Acc:HGNC:14678]
Mouse
Dog
potassium channel tetramerization domain containing 12
Cow
potassium channel tetramerization domain containing 12
Opossum
potassium channel tetramerization domain containing 12
Publication Statistics
PubMed Score 32.85
PubMed score by year
PubTator Score 22.14
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title