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Tchem
KCTD11
BTB/POZ domain-containing protein KCTD11

Protein Summary
Description
Plays a role as a marker and a regulator of neuronal differentiation; Up-regulated by a variety of neurogenic signals, such as retinoic acid, epidermal growth factor/EGF and NGFB/nerve growth factor. Induces apoptosis, growth arrest and the expression of cyclin-dependent kinase inhibitor CDKN1B. Plays a role as a tumor repressor and inhibits cell growth and tumorigenicity of medulloblastoma (MDB). Acts as probable substrate-specific adapter for a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex towards HDAC1. Functions as antagonist of the Hedgehog pathway on cell proliferation and differentiation by affecting the nuclear transfer of transcription factor GLI1, thus maintaining cerebellar granule cells in undifferentiated state, this effect probably occurs via HDAC1 down-regulation, keeping GLI1 acetylated and inactive. When knock-down, Hedgehog antagonism is impaired and proliferation of granule cells is sustained. Activates the caspase cascade.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000576980
  • ENSP00000495203
  • ENSG00000213859

Symbol
  • C17orf36
  • REN
  • REN
  • KCASH1
  • C17orf36
  • REN/KCTD11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor binding site profile
0.68
cell type or tissue
0.65
transcription factor
0.62
biological process
0.58


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.97   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 124   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.97   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 124   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (39)
KCTD5
Tbio
Novelty:  0.07740057
Score:  0.715
Data Source:  STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.688
Data Source:  STRINGDB
ACAP1
Tbio
Novelty:  0.04481025
Score:  0.686
Data Source:  STRINGDB
KCTD8
Tbio
Novelty:  0.13877221
Score:  0.669
Data Source:  STRINGDB
KCTD20
Tdark
Novelty:  0.47655751
Score:  0.644
Data Source:  STRINGDB
ZNF644
Tbio
Family:  TF
Novelty:  0.12816167
Score:  0.633
Data Source:  STRINGDB
NEUROG1
Tbio
Family:  TF
Novelty:  0.00494095
Score:  0.627
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.621
Data Source:  STRINGDB
KCTD12
Tchem
Novelty:  0.0386637
Score:  0.6
Data Source:  STRINGDB
KCTD18
Tdark
Novelty:  0.8176728
Score:  0.591
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (1)
Find Similar Targets
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
UniProt
Protein modification; protein ubiquitination.
Name
Explore in Pharos
Explore in Source
Protein modification; protein ubiquitination.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (46)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
5
4
1.3
98.7
birth weight
2
2
2
89.8
alkaline phosphatase measurement
1
2
2
79.4
autoimmune thyroid disease
1
1
0
1.1
74.8
valine measurement
4
1
3
8.5
73.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
1.3
98.7
birth weight
2
89.8
alkaline phosphatase measurement
2
79.4
autoimmune thyroid disease
0
1.1
74.8
valine measurement
3
8.5
73.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 11
VGNC:12321
468442
Mouse
MGI:2448712
216858
Rat
RGD:1307125
363634
Horse
potassium channel tetramerization domain containing 11
VGNC:19317
100147121
Cow
potassium channel tetramerization domain containing 11
VGNC:30501
539167
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium channel tetramerization domain containing 11
Mouse
Rat
Horse
potassium channel tetramerization domain containing 11
Cow
potassium channel tetramerization domain containing 11
Publication Statistics
PubMed Score 12.97
PubMed score by year
PubTator Score 9.88
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title