KCTD1
BTB/POZ domain-containing protein KCTD1
Protein Summary
May repress the transcriptional activity of AP-2 family members, including TFAP2A, TFAP2B and TFAP2C to various extent. This gene encodes a protein containing a BTB (Broad-complex, tramtrack and bric a brac), also known as a POZ (POxvirus and zinc finger) protein-protein interaction domain. The encoded protein negatively regulates the AP-2 family of transcription factors and the Wnt signaling pathway. A mechanism for the modulation of Wnt signaling has been proposed in which the encoded protein enhances ubiquitination and degradation of the beta-catenin protein. Mutations in this gene have been identified in Scalp-ear-nipple (SEN) syndrome. [provided by RefSeq, May 2017]
- ENST00000317932
- ENSP00000314831
- ENSG00000134504
- ENST00000408011
- ENSP00000384367
- ENST00000417602
- ENSP00000408405
- ENST00000579973
- ENSP00000464170
- C18orf5
- C18orf5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 0.75 | ||
transcription factor | 0.69 | ||
transcription factor perturbation | 0.61 | ||
biological process | 0.56 | ||
tissue sample | 0.53 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.05 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 102 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.05 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 102 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0