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Tclin
KCNV2
Potassium voltage-gated channel subfamily V member 2

Protein Summary
Description
Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382082
  • ENSP00000371514
  • ENSG00000168263

Symbol
  • Kv8.2
  • RCD3B
  • KV11.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.79
cell line
0.72
tissue sample
0.69
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.51   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.51   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (144)
MTHFR
Tbio
Family:  Enzyme
Novelty:  0.00018162
p_int:  0.997669786
p_ni:  0.002330214
Score:  0.248
Data Source:  BioPlex,STRINGDB
HSPA8
Tchem
Novelty:  0.00081014
p_int:  0.909000659
p_ni:  0.090999341
Score:  0.179
Data Source:  BioPlex,STRINGDB
AMZ2
Tdark
Family:  Enzyme
Novelty:  0.27424719
p_int:  0.778421225
p_ni:  0.221578775
Score:  0.309
Data Source:  BioPlex,STRINGDB
PDE6H
Tclin
Family:  Enzyme
Novelty:  0.0524804
Score:  0.929
Data Source:  STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.926
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.924
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.92
Data Source:  STRINGDB
GUCA1A
Tbio
Family:  Enzyme
Novelty:  0.01003665
Score:  0.81
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor measurement
3
5
5
98.2
hemoglobin measurement
3
3
3
92.3
hematocrit
3
2
3
89.5
low density lipoprotein cholesterol measurement
6
1
6
75.9
platelet count
1
1
1
74.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vascular endothelial growth factor measurement
5
98.2
hemoglobin measurement
3
92.3
hematocrit
3
89.5
low density lipoprotein cholesterol measurement
6
75.9
platelet count
1
74.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel modifier subfamily V member 2
VGNC:8902
473160
Macaque
potassium voltage-gated channel modifier subfamily V member 2
696487
Mouse
MGI:2670981
240595
Rat
RGD:1309271
294065
Dog
potassium voltage-gated channel modifier subfamily V member 2
VGNC:42298
609438
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel modifier subfamily V member 2
Macaque
potassium voltage-gated channel modifier subfamily V member 2
Mouse
Rat
Dog
potassium voltage-gated channel modifier subfamily V member 2
Publication Statistics
PubMed Score 47.51
PubMed score by year
PubTator Score 41.97
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title