Tclin KCNV1 Potassium voltage-gated channel subfamily V member 1

Protein Summary

Description

Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This protein is essentially present in the brain, and its role might be to inhibit the function of a particular class of outward rectifier potassium channel types. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q6PIU1
• Q9UHJ4

Gene Name

• KCNV1

Ensembl ID

• ENST00000297404
• ENSP00000297404
• ENSG00000164794
• ENST00000524391
• ENSP00000435954

Symbol

• HNKA
• KCNB3
• KV2.3
• KV8.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.9
cell type or tissue	0.8
histone modification site profile	0.55
microRNA	0.52

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / V Subfamily / Kv8.1/kcnv1 Sub-subfamily / Potassium Voltage-gated Channel Subfamily V Member 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.99   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 103   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.99   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3