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Tbio
KCNU1
Potassium channel subfamily U member 1

Protein Summary
Description
Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May represent the primary spermatozoan K(+) current. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+). Critical for fertility. May play an important role in sperm osmoregulation required for the acquisition of normal morphology and motility when faced with osmotic challenges, such as those experienced after mixing with seminal fluid and entry into the vagina. This gene encodes a member of the potassium channel family of proteins. The encoded voltage-gated ion channel allows the outward flow of potassium ions during plasma membrane hyperpolarization in sperm. Opening of this channel may be regulated by calcium ion levels. Homozygous knockout mice that lack the related mouse gene exhibit male sterility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399881
  • ENSP00000382770
  • ENSG00000215262

Symbol
  • KCNMA3
  • KCNMC1
  • SLO3
  • KCa5
  • Slo3
  • KCNMC1
  • KCa5.1
  • Kcnma3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.9
molecular function
0.86
cell type or tissue
0.67
cell line
0.61
tissue
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.11   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 58.11   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (50)
KCNN1
Tchem
Family:  IC
Novelty:  0.04266994
Score:  0.914
Data Source:  STRINGDB
KCNMB1
Tbio
Family:  IC
Novelty:  0.00736653
Score:  0.905
Data Source:  STRINGDB
KCNN2
Tchem
Family:  IC
Novelty:  0.01865346
Score:  0.903
Data Source:  STRINGDB
KCNN4
Tchem
Family:  IC
Novelty:  0.00244935
Score:  0.898
Data Source:  STRINGDB
KCNMB4
Tbio
Family:  IC
Novelty:  0.05362954
Score:  0.891
Data Source:  STRINGDB
KCNN3
Tchem
Family:  IC
Novelty:  0.00227544
Score:  0.887
Data Source:  STRINGDB
KCNMB2
Tbio
Family:  IC
Novelty:  0.4425394
Score:  0.846
Data Source:  STRINGDB
KCNMB3
Tbio
Family:  IC
Novelty:  0.08717845
Score:  0.822
Data Source:  STRINGDB
PRKG1
Tchem
Family:  Kinase
Novelty:  0.0014943
Score:  0.815
Data Source:  STRINGDB
KCNMA1
Tclin
Family:  IC
Novelty:  0.00088182
Score:  0.812
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (6)
Fertilization (R-HSA-1187000)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fertilization
Reactome
Reproduction
Reactome
Sperm Motility And Taxes
Name
Explore in Pharos
Explore in Source
Fertilization
Reproduction
Sperm Motility And Taxes
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
breast size
2
3
3
86.6
type 2 diabetes mellitus
3
3
2
1.1
69.2
mammographic density measurement
2
1
2
51.6
non-dense area measurement
1
1
1
48.8
educational attainment
1
1
1
42.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
breast size
3
86.6
type 2 diabetes mellitus
2
1.1
69.2
mammographic density measurement
2
51.6
non-dense area measurement
1
48.8
educational attainment
1
42.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily U member 1
VGNC:7595
464107
Macaque
potassium calcium-activated channel subfamily U member 1
697748
Mouse
MGI:1202300
16532
Rat
RGD:1585877
680912
Dog
potassium calcium-activated channel subfamily U member 1
VGNC:42296
482856
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily U member 1
Macaque
potassium calcium-activated channel subfamily U member 1
Mouse
Rat
Dog
potassium calcium-activated channel subfamily U member 1
Publication Statistics
PubMed Score 58.11
PubMed score by year
PubTator Score 19.87
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title