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Tchem
KCNT2
Potassium channel subfamily T member 2

Protein Summary
Description
Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels (PubMed:14684870, PubMed:16687497, PubMed:29069600). Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane (PubMed:16687497) (By similarity). Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRM1 (PubMed:16687497).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294725
  • ENSP00000294725
  • ENSG00000162687
  • ENST00000367433
  • ENSP00000356403
  • ENST00000609185
  • ENSP00000476657

Symbol
  • SLICK
  • SLICK
  • EIEE57
  • KCa4.2
  • SLO2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
gene perturbation
0.74
histone modification site profile
0.72
phenotype
0.68
tissue sample
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.71   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.71   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2