Tclin KCNS2 Potassium voltage-gated channel subfamily S member 2

Protein Summary

Description

Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.

Uniprot Accession IDs

• Q9ULS6
• A8KAN1

Gene Name

• KCNS2

Ensembl ID

• ENST00000287042
• ENSP00000287042
• ENSG00000156486
• ENST00000521839
• ENSP00000430712

Symbol

• KIAA1144
• KV9.2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.99
molecular function	0.84
PubMedID	0.57
cell line	0.55
gene perturbation	0.53

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / S Subfamily / Kv9.2/kcns2 Sub-subfamily / Potassium Voltage-gated Channel Subfamily S Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 170   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.76   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3