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Tclin
KCNS2
Potassium voltage-gated channel subfamily S member 2

Protein Summary
Description
Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1 and KCNB2; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1 and KCNB2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287042
  • ENSP00000287042
  • ENSG00000156486
  • ENST00000521839
  • ENSP00000430712

Symbol
  • KIAA1144
  • KV9.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.84
PubMedID
0.57
cell line
0.55
gene perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.08   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.08   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (115)
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.959
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.947
Data Source:  STRINGDB
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.93
Data Source:  STRINGDB
P35544
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
P62861
Tbio
Novelty:  0.01170009
Score:  0.788
Data Source:  STRINGDB
ZCCHC14
Tbio
Novelty:  0.18393973
Score:  0.73
Data Source:  STRINGDB
STK33
Tchem
Family:  Kinase
Novelty:  0.05051872
Score:  0.723
Data Source:  STRINGDB
RPL18A
Tbio
Novelty:  0.04612948
Score:  0.668
Data Source:  STRINGDB
PDLIM4
Tbio
Novelty:  0.01308013
Score:  0.63
Data Source:  STRINGDB
RPL37A
Tbio
Novelty:  0.03475061
Score:  0.605
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
susceptibility to childhood ear infection measurement
1
1
0
1.1
2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
susceptibility to childhood ear infection measurement
0
1.1
2
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel modifier subfamily S member 2
VGNC:12306
472828
Macaque
potassium voltage-gated channel modifier subfamily S member 2
703802
Mouse
MGI:1197011
16539
Rat
RGD:621525
66022
Dog
potassium voltage-gated channel modifier subfamily S member 2
VGNC:42294
481979
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel modifier subfamily S member 2
Macaque
potassium voltage-gated channel modifier subfamily S member 2
Mouse
Rat
Dog
potassium voltage-gated channel modifier subfamily S member 2
Publication Statistics
PubMed Score 2.08
PubMed score by year
PubTator Score 1.59
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title