Tclin KCNQ4 Potassium voltage-gated channel subfamily KQT member 4

Protein Summary

Description

Probably important in the regulation of neuronal excitability. May underlie a potassium current involved in regulating the excitability of sensory cells of the cochlea. KCNQ4 channels are blocked by linopirdin, XE991 and bepridil, whereas clofilium is without significant effect. Muscarinic agonist oxotremorine-M strongly suppress KCNQ4 current in CHO cells in which cloned KCNQ4 channels were coexpressed with M1 muscarinic receptors. The protein encoded by this gene forms a potassium channel that is thought to play a critical role in the regulation of neuronal excitability, particularly in sensory cells of the cochlea. The current generated by this channel is inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. The encoded protein can form a homomultimeric potassium channel or possibly a heteromultimeric channel in association with the protein encoded by the KCNQ3 gene. Defects in this gene are a cause of nonsyndromic sensorineural deafness type 2 (DFNA2), an autosomal dominant form of progressive hearing loss. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P56696
• O96025

Gene Name

• KCNQ4

Ensembl ID

• ENST00000347132
• ENSP00000262916
• ENSG00000117013
• ENST00000509682
• ENSP00000423756
• ENST00000642618
• ENSP00000494128

Symbol

• DFNA2
• KV7.4
• DFNA2A

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.85
molecular function	0.79
microRNA	0.69
transcription factor	0.65
cellular component	0.63

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Kqt Subfamily / Kv7.4/kcnq4 Sub-subfamily / Potassium Voltage-gated Channel Subfamily Kqt Member 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.27   (req: < 5)

Gene RIFs: 66   (req: <= 3)

Antibodies: 333   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 194.27   (req: >= 5)

Gene RIFs: 66   (req: > 3)

Antibodies: 333   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 21

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5