Tclin KCNQ2 Potassium voltage-gated channel subfamily KQT member 2

Protein Summary

Description

Associates with KCNQ3 to form a potassium channel with essentially identical properties to the channel underlying the native M-current, a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs. Therefore, it is important in the regulation of neuronal excitability. KCNQ2/KCNQ3 current is blocked by linopirdine and XE991, and activated by the anticonvulsant retigabine (PubMed:9836639, PubMed:11572947, PubMed:14534157, PubMed:12742592, PubMed:17872363). As the native M-channel, the potassium channel composed of KCNQ2 and KCNQ3 is also suppressed by activation of the muscarinic acetylcholine receptor CHRM1 (PubMed:10684873). The M channel is a slowly activating and deactivating potassium channel that plays a critical role in the regulation of neuronal excitability. The M channel is formed by the association of the protein encoded by this gene and a related protein encoded by the KCNQ3 gene, both integral membrane proteins. M channel currents are inhibited by M1 muscarinic acetylcholine receptors and activated by retigabine, a novel anti-convulsant drug. Defects in this gene are a cause of benign familial neonatal convulsions type 1 (BFNC), also known as epilepsy, benign neonatal type 1 (EBN1). At least five transcript variants encoding five different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O43526
• O43796
• O75580
• O95845
• Q4VXP4
• Q4VXR6
• Q5VYT8
• Q96J59
• Q99454

Gene Name

• KCNQ2

Ensembl ID

• ENST00000344425
• ENSP00000345523
• ENSG00000075043
• ENST00000344462
• ENSP00000339611
• ENST00000359125
• ENSP00000352035
• ENST00000360480
• ENSP00000353668
• ENST00000626839
• ENSP00000486706

Symbol

• EBN
• BFNC
• EBN1
• ENB1
• HNSPC
• KV7.2
• KCNA11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.96
protein domain	0.92
molecular function	0.88
PubMedID	0.73
cellular component	0.72

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Kqt Subfamily / Kv7.2/kcnq2 Sub-subfamily / Potassium Voltage-gated Channel Subfamily Kqt Member 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 653.87   (req: < 5)

Gene RIFs: 134   (req: <= 3)

Antibodies: 258   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 653.87   (req: >= 5)

Gene RIFs: 134   (req: > 3)

Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 73

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5