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Tclin
KCNQ1
Potassium voltage-gated channel subfamily KQT member 1

Protein Summary
Description
Potassium channel that plays an important role in a number of tissues, including heart, inner ear, stomach and colon (By similarity) (PubMed:10646604). Associates with KCNE beta subunits that modulates current kinetics (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505, PubMed:19687231). Induces a voltage-dependent by rapidly activating and slowly deactivating potassium-selective outward current (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:10646604, PubMed:11101505). Promotes also a delayed voltage activated potassium current showing outward rectification characteristic (By similarity). During beta-adrenergic receptor stimulation participates in cardiac repolarization by associating with KCNE1 to form the I(Ks) cardiac potassium current that increases the amplitude and slows down the activation kinetics of outward potassium current I(Ks) (By similarity) (PubMed:9312006, PubMed:9108097, PubMed:8900283, PubMed:1064 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000155840
  • ENSP00000155840
  • ENSG00000053918
  • ENST00000335475
  • ENSP00000334497

Symbol
  • KCNA8
  • KCNA9
  • KVLQT1
  • LQT
  • RWS
  • WRS
  • LQT1
  • SQT2
  • ATFB1
  • ATFB3
  • JLNS1
  • KCNA8
  • KCNA9
  • Kv1.9
  • Kv7.1
  • KVLQT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
trait
0.97
biological process
0.9
phenotype
0.88
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1338.77   (req: < 5)
Gene RIFs: 399   (req: <= 3)
Antibodies: 440   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1338.77   (req: >= 5)
Gene RIFs: 399   (req: > 3)
Antibodies: 440   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3