KCNN4
Intermediate conductance calcium-activated potassium channel protein 4
Protein Summary
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
- ENST00000262888
- ENSP00000262888
- ENSG00000104783
- ENST00000648319
- ENSP00000496939
- IK1
- IKCA1
- KCA4
- SK4
- IK
- IK1
- SK4
- DHS2
- KCA4
- hSK4
- IKCA1
- hKCa4
- KCa3.1
- hIKCa1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.91 | ||
molecular function | 0.91 | ||
kinase perturbation | 0.88 | ||
small molecule perturbation | 0.74 | ||
biological process | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 504.1 (req: < 5)
Gene RIFs: 119 (req: <= 3)
Antibodies: 269 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 504.1 (req: >= 5)
Gene RIFs: 119 (req: > 3)
Antibodies: 269 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 48
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (48)
Protein-Protein Interactions (88)
Nearest Tclin Targets
Pathways (7)
Reactome (3)
KEGG (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Ca2+ activated K+ channels | ||||
Reactome | Neuronal System | ||||
Reactome | Potassium Channels | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Ca2+ activated K+ channels | ||||
Neuronal System | ||||
Potassium Channels | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (6)
Components (5)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (25)
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 2 | 2 | 94.1 | |||||
apolipoprotein B measurement | 1 | 2 | 2 | 92.4 | |||||
low density lipoprotein cholesterol measurement | 1 | 2 | 2 | 90.8 | |||||
hemoglobin measurement | 3 | 2 | 3 | 82.7 | |||||
monocyte count | 1 | 1 | 1 | 81.9 | |||||
Items per page:
1 – 5 of 25
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
monocyte percentage of leukocytes | 2 | 94.1 | |||||
apolipoprotein B measurement | 2 | 92.4 | |||||
low density lipoprotein cholesterol measurement | 2 | 90.8 | |||||
hemoglobin measurement | 3 | 82.7 | |||||
monocyte count | 1 | 81.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | potassium calcium-activated channel subfamily N member 4 | VGNC:7484 | 456098 | |||||
Mouse | MGI:1277957 | 16534 | ||||||
Rat | RGD:621476 | 65206 | ||||||
Dog | potassium calcium-activated channel subfamily N member 4 | VGNC:42287 | 484464 | |||||
Cow | potassium calcium-activated channel subfamily N member 4 | VGNC:30486 | 534591 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | potassium calcium-activated channel subfamily N member 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | potassium calcium-activated channel subfamily N member 4 | |||||
Cow | potassium calcium-activated channel subfamily N member 4 | |||||
Publication Statistics
PubMed Score 504.10
PubMed score by year
PubTator Score 307.22
PubTator score by year
Patents
Patents by year
Related Publications
GeneRif Annotations (119)
Items per page:
0 of 0
PMID | Text |
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