Tchem KCNN4 Intermediate conductance calcium-activated potassium channel protein 4

Protein Summary

Description

Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O15554
• Q53XR4
• SK4

Gene Name

• KCNN4

Ensembl ID

• ENST00000262888
• ENSP00000262888
• ENSG00000104783
• ENST00000648319
• ENSP00000496939

Symbol

• IK1
• IKCA1
• KCA4
• SK4
• IK
• IK1
• SK4
• DHS2
• KCA4
• hSK4
• IKCA1
• hKCa4
• KCa3.1
• hIKCa1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
molecular function	0.91
kinase perturbation	0.88
small molecule perturbation	0.74
biological process	0.69

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Potassium Channel / Intermediate Conductance Calcium-activated Potassium Channel Protein 4

Protein / Transporter / Ion Channel / Potassium Channel / Voltage-gated Potassium Channel / Intermediate Conductance Calcium-activated Potassium Channel Protein 4

DTO Classes

Protein / Ion Channel / Potassium Channel Family / Calcium-activated Subfamily / Intermediate Conductance Calcium-activated Potassium Channel Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.37   (req: < 5)

Gene RIFs: 140   (req: <= 3)

Antibodies: 269   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.37   (req: >= 5)

Gene RIFs: 140   (req: > 3)

Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 58

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4