KCNN4
Intermediate conductance calcium-activated potassium channel protein 4
Protein Summary
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
- ENST00000262888
- ENSP00000262888
- ENSG00000104783
- ENST00000648319
- ENSP00000496939
- IK1
- IKCA1
- KCA4
- SK4
- IK
- IK1
- SK4
- DHS2
- KCA4
- hSK4
- IKCA1
- hKCa4
- KCa3.1
- hIKCa1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.91 | ||
molecular function | 0.91 | ||
kinase perturbation | 0.88 | ||
small molecule perturbation | 0.74 | ||
biological process | 0.69 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 561.37 (req: < 5)
Gene RIFs: 144 (req: <= 3)
Antibodies: 269 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 561.37 (req: >= 5)
Gene RIFs: 144 (req: > 3)
Antibodies: 269 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 58
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4