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Tchem
KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

Protein Summary
Description
Forms a voltage-independent potassium channel that is activated by intracellular calcium (PubMed:26148990). Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells (PubMed:17157250, PubMed:18796614). Plays a role in the late stages of EGF-induced macropinocytosis (PubMed:24591580). The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262888
  • ENSP00000262888
  • ENSG00000104783
  • ENST00000648319
  • ENSP00000496939

Symbol
  • IK1
  • IKCA1
  • KCA4
  • SK4
  • IK
  • IK1
  • SK4
  • DHS2
  • KCA4
  • hSK4
  • IKCA1
  • hKCa4
  • KCa3.1
  • hIKCa1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
molecular function
0.91
kinase perturbation
0.88
small molecule perturbation
0.74
biological process
0.69


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.37   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 561.37   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 58
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4