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Tchem
KCNN1
Small conductance calcium-activated potassium channel protein 1

Protein Summary
Description
Forms a voltage-independent potassium channel activated by intracellular calcium. Activation is followed by membrane hyperpolarization. Thought to regulate neuronal excitability by contributing to the slow component of synaptic afterhyperpolarization. The channel is blocked by apamin (By similarity). Action potentials in vertebrate neurons are followed by an afterhyperpolarization (AHP) that may persist for several seconds and may have profound consequences for the firing pattern of the neuron. Each component of the AHP is kinetically distinct and is mediated by different calcium-activated potassium channels. The protein encoded by this gene is activated before membrane hyperpolarization and is thought to regulate neuronal excitability by contributing to the slow component of synaptic AHP. The encoded protein is an integral membrane protein that forms a voltage-independent calcium-activated channel with three other calmodulin-binding subunits. This gene is a member of the KCNN family o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222249
  • ENSP00000476519
  • ENSG00000105642

Symbol
  • SK
  • SK1
  • hSK1
  • SKCA1
  • KCa2.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
cell type or tissue
0.74
small molecule perturbation
0.64
transcription factor
0.64
disease perturbation
0.56


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.3   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.3   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 17
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (46)
KCNMA1
Tclin
Family:  IC
Novelty:  0.00088182
Score:  0.955
Data Source:  STRINGDB
KCNU1
Tbio
Family:  IC
Novelty:  0.02284336
Score:  0.914
Data Source:  STRINGDB
KCNMB1
Tbio
Family:  IC
Novelty:  0.00736653
Score:  0.89
Data Source:  STRINGDB
KCNMB4
Tbio
Family:  IC
Novelty:  0.05362954
Score:  0.832
Data Source:  STRINGDB
KCNMB3
Tbio
Family:  IC
Novelty:  0.08717845
Score:  0.827
Data Source:  STRINGDB
KCNN4
Tchem
Family:  IC
Novelty:  0.00244935
Score:  0.815
Data Source:  STRINGDB
KCNN3
Tchem
Family:  IC
Novelty:  0.00227544
Score:  0.81
Data Source:  Reactome,STRINGDB
KCNN2
Tchem
Family:  IC
Novelty:  0.01865346
Score:  0.809
Data Source:  Reactome,STRINGDB
KCNMB2
Tbio
Family:  IC
Novelty:  0.4425394
Score:  0.807
Data Source:  STRINGDB
CALM1
Tclin
Novelty:  0.00308267
Score:  0.786
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (5)
Ca2+ activated K+ channels (R-HSA-1296052)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca2+ activated K+ channels
Reactome
Neuronal System
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Ca2+ activated K+ channels
Neuronal System
Potassium Channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
5
5
91.8
monocyte percentage of leukocytes
2
1
2
81.9
Oral ulcer
1
1
0
1.1
78.5
reticulocyte measurement
2
3
3
78.4
monocyte count
1
1
1
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
5
91.8
monocyte percentage of leukocytes
2
81.9
Oral ulcer
0
1.1
78.5
reticulocyte measurement
3
78.4
monocyte count
1
72.3
Find similar targets by:
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
potassium calcium-activated channel subfamily N member 1
720091
Mouse
MGI:1933993
84036
Rat
RGD:2962
54261
Dog
potassium calcium-activated channel subfamily N member 1
VGNC:42284
484829
Cow
potassium calcium-activated channel subfamily N member 1
VGNC:30483
408008
Species
Name
OMA
EggNOG
Inparanoid
Macaque
potassium calcium-activated channel subfamily N member 1
Mouse
Rat
Dog
potassium calcium-activated channel subfamily N member 1
Cow
potassium calcium-activated channel subfamily N member 1
Publication Statistics
PubMed Score 17.30
PubMed score by year
PubTator Score 32.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title