Tbio KCNMB4 Calcium-activated potassium channel subunit beta-4

Protein Summary

Description

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May decrease KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations. Makes KCNMA1 channel resistant to 100 nM charybdotoxin (CTX) toxin concentrations. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which slows activation kinetics, leads to steeper calcium sensitivity, and shifts the voltage range of current activation to more negative potentials than does the beta 1 subunit. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q86W47
• Q8IVR3
• Q9NPA4
• Q9P0G5

Gene Name

• KCNMB4

Ensembl ID

• ENST00000258111
• ENSP00000258111
• ENSG00000135643

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.86
histone modification site profile	0.84
gene perturbation	0.71
PubMedID	0.61
tissue sample	0.57

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Voltage-gated Ion Channel / Voltage-gated Potassium Channel / Calcium-activated Potassium Channel Subunit Beta-4

Protein / Transporter / Ion Channel / Potassium Channel / Voltage-gated Potassium Channel / Calcium-activated Potassium Channel Subunit Beta-4

DTO Classes

Protein / Ion Channel / Calcium-activated Potassium Channel Auxiliary Subunit Slowpoke- (Slo) Family / Kcnmb/kcnmb4 Subfamily / Calcium-activated Potassium Channel Subunit Beta-4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.13   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 162   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.13   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 162   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0