KCNMB3
Calcium-activated potassium channel subunit beta-3
Protein Summary
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Alters the functional properties of the current expressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform 4 partially inactivate the current of KCNBMA. Isoform 4 induces a fast and incomplete inactivation of KCNMA1 channel that is detectable only at large depolarizations. In contrast, isoform 1 does not induce detectable inactivation of KCNMA1. Two or more subunits of KCNMB3 are required to block the KCNMA1 tetramer. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or s ...more
- ENST00000314235
- ENSP00000319370
- ENSG00000171121
- ENST00000349697
- ENSP00000327866
- ENST00000392685
- ENSP00000376451
- ENST00000392686
- ENSP00000376452
- ENST00000485523
- ENSP00000418536
- ENST00000497599
- ENSP00000417091
- KCNMB2
- KCNMBL
- HBETA3
- KCNMB2
- KCNMBL
- BKBETA3
- SLOBETA3
- SLO-BETA-3
- K(VCA)BETA-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.81 | ||
cell type or tissue | 0.62 | ||
small molecule perturbation | 0.57 | ||
tissue | 0.57 | ||
transcription factor | 0.52 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.55 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 258 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 9.55 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 258 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0