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Tbio
KCNMB1
Calcium-activated potassium channel subunit beta-1

Protein Summary
Description
Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Increases the apparent Ca(2+)/voltage sensitivity of the KCNMA1 channel. It also modifies KCNMA1 channel kinetics and alters its pharmacological properties. It slows down the activation and the deactivation kinetics of the channel. Acts as a negative regulator of smooth muscle contraction by enhancing the calcium sensitivity to KCNMA1. Its presence is also a requirement for internal binding of the KCNMA1 channel opener dehydrosoyasaponin I (DHS-1) triterpene glycoside and for external binding of the agonist hormone 17-beta-estradiol (E2). Increases the binding activity of charybdotoxin (CTX) toxin to KCNMA1 peptide blocker by increasing the CTX association rate and decreasing the dissociation rate. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fu ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274629
  • ENSP00000274629
  • ENSG00000145936
  • ENST00000521859
  • ENSP00000427940

Symbol
  • hbeta1
  • BKbeta1
  • SLO-BETA
  • hslo-beta
  • K(VCA)beta
  • slo-beta-1
  • k(VCA)beta-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.81
gene perturbation
0.73
cell type or tissue
0.66
tissue sample
0.61
biological term
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.39   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 133.39   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (60)
KCNMA1
Tclin
Family:  IC
Novelty:  0.00088182
Score:  0.989
Data Source:  Reactome,STRINGDB
PRKG2
Tchem
Family:  Kinase
Novelty:  0.0138455
Score:  0.907
Data Source:  Reactome,STRINGDB
KCNU1
Tbio
Family:  IC
Novelty:  0.02284336
Score:  0.905
Data Source:  STRINGDB
KCNN1
Tchem
Family:  IC
Novelty:  0.04266994
Score:  0.89
Data Source:  STRINGDB
KCNN4
Tchem
Family:  IC
Novelty:  0.00244935
Score:  0.884
Data Source:  STRINGDB
KCNN2
Tchem
Family:  IC
Novelty:  0.01865346
Score:  0.876
Data Source:  STRINGDB
KCNMB4
Tbio
Family:  IC
Novelty:  0.05362954
Score:  0.857
Data Source:  Reactome,STRINGDB
KCNN3
Tchem
Family:  IC
Novelty:  0.00227544
Score:  0.853
Data Source:  STRINGDB
KCNMB3
Tbio
Family:  IC
Novelty:  0.08717845
Score:  0.832
Data Source:  Reactome,STRINGDB
KCNMB2
Tbio
Family:  IC
Novelty:  0.4425394
Score:  0.811
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
Pathways (10)
Ca2+ activated K+ channels (R-HSA-1296052)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ca2+ activated K+ channels
Reactome
Hemostasis
Reactome
Neuronal System
Reactome
Nitric oxide stimulates guanylate cyclase
Reactome
Platelet homeostasis
Name
Explore in Pharos
Explore in Source
Ca2+ activated K+ channels
Hemostasis
Neuronal System
Nitric oxide stimulates guanylate cyclase
Platelet homeostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
1
1
67.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
viral load
1
67.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily M regulatory beta subunit 1
VGNC:4058
462258
Macaque
potassium calcium-activated channel subfamily M regulatory beta subunit 1
700624
Mouse
MGI:1334203
16533
Rat
RGD:2961
29747
Dog
potassium calcium-activated channel subfamily M regulatory beta subunit 1
VGNC:42282
403983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium calcium-activated channel subfamily M regulatory beta subunit 1
Macaque
potassium calcium-activated channel subfamily M regulatory beta subunit 1
Mouse
Rat
Dog
potassium calcium-activated channel subfamily M regulatory beta subunit 1
Publication Statistics
PubMed Score 133.39
PubMed score by year
PubTator Score 2151.65
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title