KCNK9
Potassium channel subfamily K member 9
Protein Summary
pH-dependent, voltage-insensitive, background potassium channel protein. This gene encodes a protein that contains multiple transmembrane regions and two pore-forming P domains and functions as a pH-dependent potassium channel. Amplification and overexpression of this gene have been observed in several types of human carcinomas. This gene is imprinted in the brain, with preferential expression from the maternal allele. A mutation in this gene was associated with Birk-Barel dysmorphism syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
- ENST00000303015
- ENSP00000302166
- ENSG00000169427
- ENST00000520439
- ENSP00000430676
- ENST00000522317
- ENSP00000429847
- ENST00000648164
- ENSP00000498198
- ENST00000650269
- ENSP00000496915
- TASK3
- KT3.2
- TASK3
- K2p9.1
- TASK-3
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
cell line | 0.68 | ||
hub protein | 0.58 | ||
protein domain | 0.58 | ||
tissue | 0.57 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 216.12 (req: < 5)
Gene RIFs: 53 (req: <= 3)
Antibodies: 84 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 216.12 (req: >= 5)
Gene RIFs: 53 (req: > 3)
Antibodies: 84 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 4
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 43
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 6