Tchem KCNK17 Potassium channel subfamily K member 17

Protein Summary

Description

Outward rectifying potassium channel. Produces rapidly activating and non-inactivating outward rectifier K(+) currents. The protein encoded by this gene belongs to the family of potassium channel proteins containing two pore-forming P domains. This channel is an open rectifier which primarily passes outward current under physiological K+ concentrations. This gene is activated at alkaline pH. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• Q96T54
• E9PB46
• Q5TCF4
• Q8TAW4
• Q9BXD1
• Q9H592

Gene Name

• KCNK17

Ensembl ID

• ENST00000373231
• ENSP00000362328
• ENSG00000124780
• ENST00000453413
• ENSP00000401271

Symbol

• TALK2
• TASK4
• TALK2
• TASK4
• TALK-2
• TASK-4
• K2p17.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.79
cell type or tissue	0.69
trait	0.61
cell line	0.6
phenotype	0.54

Protein Classes

DTO Classes

Protein / Ion Channel / Two Pore Domain Potassium Channel Family / Potassium Channel Subfamily K Member 17

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.03   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 54   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.03   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0