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Tbio
KCNJ9
G protein-activated inward rectifier potassium channel 3

Protein Summary
Description
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity). Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. It associates with another G-protein-activated potassium channel to form a heteromultimeric pore-forming complex. [provided by RefSeq ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368088
  • ENSP00000357067
  • ENSG00000162728

Symbol
  • GIRK3
  • GIRK3
  • KIR3.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
gene perturbation
0.68
trait
0.61
PubMedID
0.59
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.59   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.59   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (214)
GNB1
Tbio
Novelty:  0.02477955
Score:  0.972
Data Source:  Reactome,STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.969
Data Source:  Reactome,STRINGDB
GABBR1
Tclin
Family:  GPCR
Novelty:  0.00086493
Score:  0.958
Data Source:  Reactome,STRINGDB
GABBR2
Tclin
Family:  GPCR
Novelty:  0.00739771
Score:  0.955
Data Source:  Reactome,STRINGDB
GNG3
Tbio
Novelty:  0.16941216
Score:  0.947
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.937
Data Source:  Reactome,STRINGDB
GNG7
Tbio
Novelty:  0.08478455
Score:  0.931
Data Source:  STRINGDB
GNG8
Tdark
Novelty:  0.00590503
Score:  0.926
Data Source:  STRINGDB
GNGT2
Tbio
Novelty:  0.0468008
Score:  0.925
Data Source:  STRINGDB
GNG4
Tbio
Novelty:  0.14371438
Score:  0.917
Data Source:  STRINGDB
Nearest Tclin Targets (12)
Explore Nearest Tclin Targets
1 – 5 of 12
OXTR
Tclin
Family:  GPCR
KEGG Distance:  2
Common Pathways:  1
CNR1
Tclin
Family:  GPCR
KEGG Distance:  2
Common Pathways:  1
HTR1D
Tclin
Family:  GPCR
KEGG Distance:  2
Common Pathways:  1
Pathways (22)
Activation of G protein gated Potassium channels (R-HSA-1296041)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
G protein gated Potassium channels
Reactome
GABA B receptor activation
Reactome
GABA receptor activation
Name
Explore in Pharos
Explore in Source
Activation of G protein gated Potassium channels
Activation of GABAB receptors
G protein gated Potassium channels
GABA B receptor activation
GABA receptor activation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
1
2
2
81.8
electrocardiography
1
1
3
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
granulocyte count
2
81.8
electrocardiography
3
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 9
VGNC:10678
469548
Mouse
MGI:108007
16524
Rat
RGD:621440
116560
Dog
potassium voltage-gated channel subfamily J member 9
VGNC:42269
100855823
Cow
potassium voltage-gated channel subfamily J member 9
VGNC:30464
614969
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 9
Mouse
Rat
Dog
potassium voltage-gated channel subfamily J member 9
Cow
potassium voltage-gated channel subfamily J member 9
Publication Statistics
PubMed Score 38.59
PubMed score by year
PubTator Score 17.93
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
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PMID
Text