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Tchem
KCNJ13
Inward rectifier potassium channel 13

Protein Summary
Description
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. KCNJ13 has a very low single channel conductance, low sensitivity to block by external barium and cesium, and no dependence of its inward rectification properties on the internal blocking particle magnesium. This gene encodes a member of the inwardly rectifying potassium channel family of proteins. Members of this family form ion channel pores that allow potassium ions to pass into a cell. The encoded protein belongs to a subfamily of low signal channel conductance proteins that have a low dependence on potassium concentration. Mutations in this gene are associa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233826
  • ENSP00000233826
  • ENSG00000115474
  • ENST00000409779
  • ENSP00000386408
  • ENST00000410029
  • ENSP00000386251

Symbol
  • SVD
  • LCA16
  • KIR1.4
  • KIR7.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
microRNA
0.68
cell type or tissue
0.6
gene perturbation
0.6
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.34   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.34   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (38)
KCNE3
Tbio
Family:  IC
Novelty:  0.01541806
Score:  0.86
Data Source:  STRINGDB
KCNQ1
Tclin
Family:  IC
Novelty:  0.0008956
Score:  0.859
Data Source:  STRINGDB
KCNN4
Tchem
Family:  IC
Novelty:  0.00244935
Score:  0.849
Data Source:  STRINGDB
KCNK5
Tchem
Family:  IC
Novelty:  0.00932619
Score:  0.837
Data Source:  STRINGDB
IGSF11
Tbio
Novelty:  0.07516371
Score:  0.726
Data Source:  STRINGDB
COL11A1
Tbio
Novelty:  0.00594683
Score:  0.628
Data Source:  STRINGDB
GJA5
Tbio
Novelty:  0.00195794
Score:  0.559
Data Source:  STRINGDB
EDNRB
Tclin
Family:  GPCR
Novelty:  0.00053875
Score:  0.553
Data Source:  STRINGDB
COL4A3
Tbio
Novelty:  0.00296126
Score:  0.527
Data Source:  STRINGDB
PNP
Tclin
Family:  Enzyme
Novelty:  0.0019084
Score:  0.509
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
10
4
5
1.1
85.3
mathematical ability
2
1
2
81.6
bilirubin measurement
2
3
4
76.7
self reported educational attainment
2
1
2
76.3
2
2
1
1.1
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
1.1
85.3
mathematical ability
2
81.6
bilirubin measurement
4
76.7
self reported educational attainment
2
76.3
1
1.1
75
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 13
VGNC:8359
100615579
Mouse
MGI:3781032
100040591
Rat
RGD:621661
94341
Dog
potassium voltage-gated channel subfamily J member 13
VGNC:42260
477411
Horse
potassium voltage-gated channel subfamily J member 13
VGNC:19286
100057299
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily J member 13
Mouse
Rat
Dog
potassium voltage-gated channel subfamily J member 13
Horse
potassium voltage-gated channel subfamily J member 13
Publication Statistics
PubMed Score 69.34
PubMed score by year
PubTator Score 31.33
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title