Tchem KCNJ1 ATP-sensitive inward rectifier potassium channel 1

Protein Summary

Description

In the kidney, probably plays a major role in potassium homeostasis. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This channel is activated by internal ATP and can be blocked by external barium. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P48048
• B2RMR4
• Q6LD67

Gene Name

• KCNJ1

Ensembl ID

• ENST00000324036
• ENSP00000316233
• ENSG00000151704
• ENST00000392664
• ENSP00000376432
• ENST00000392665
• ENSP00000376433
• ENST00000392666
• ENSP00000376434
• ENST00000440599
• ENSP00000406320

Symbol

• ROMK1
• ROMK
• ROMK1
• KIR1.1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	1
kinase	0.75
tissue sample	0.74
cell type or tissue	0.72
disease perturbation	0.68

Protein Classes

DTO Classes

Protein / Ion Channel / Inward Rectifier-type Potassium Channel Family / Kcnj1 Subfamily / Atp-sensitive Inward Rectifier Potassium Channel 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.98   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 255   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 433.98   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 605

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0