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Tbio
KCNIP4
Kv channel-interacting protein 4

Protein Summary
Description
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435). Modulates KCND3/Kv4.3 currents (PubMed:23576435). Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440). Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane. This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal exc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359001
  • ENSP00000351892
  • ENSG00000185774
  • ENST00000382148
  • ENSP00000371583
  • ENST00000382150
  • ENSP00000371585
  • ENST00000382152
  • ENSP00000371587
  • ENST00000447367
  • ENSP00000399080
  • ENST00000509207
  • ENSP00000423257

Symbol
  • CALP
  • KCHIP4
  • CALP
  • KCHIP4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
molecular function
0.9
disease
0.69
microRNA
0.68
cellular component
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.52   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.52   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (82)
KCNIP2
Tbio
Family:  IC
Novelty:  0.01123517
p_int:  1
Score:  0.767
Data Source:  BioPlex,Reactome,STRINGDB
KCNIP1
Tbio
Family:  IC
Novelty:  0.01790042
p_int:  0.999990666
p_wrong:  0.000009334
Score:  0.879
Data Source:  BioPlex,Reactome,STRINGDB
MTX1
Tbio
Novelty:  0.02350764
p_int:  0.999872581
p_ni:  0.000127419
Score:  0.185
Data Source:  BioPlex,STRINGDB
LACRT
Tbio
Novelty:  0.03333799
p_int:  0.998115177
p_ni:  0.001884818
p_wrong:  5e-9
Data Source:  BioPlex
SCGB1D1
Tbio
Novelty:  0.04199997
p_int:  0.980858305
p_ni:  0.000045161
p_wrong:  0.019096535
Score:  0.211
Data Source:  BioPlex,STRINGDB
PRR4
Tbio
Novelty:  0.01240966
p_int:  0.904030186
p_ni:  0.002089158
p_wrong:  0.093880657
Score:  0.241
Data Source:  BioPlex,STRINGDB
HLA-DRA
Tbio
Novelty:  0.0060214
p_int:  0.806383766
p_ni:  0.193616117
p_wrong:  1.17e-7
Score:  0.52
Data Source:  BioPlex,STRINGDB
KLK4
Tchem
Family:  Enzyme
Novelty:  0.00019849
p_int:  0.801663715
p_ni:  0.19833593
p_wrong:  3.55e-7
Score:  0.855
Data Source:  BioPlex,STRINGDB
TFPI
Tchem
Novelty:  0.00060355
p_int:  0.801663715
p_ni:  0.19833593
p_wrong:  3.55e-7
Score:  0.375
Data Source:  BioPlex,STRINGDB
ECE2
Tchem
Family:  Enzyme
Novelty:  0.03234301
p_int:  0.790896142
p_ni:  0.209103858
Score:  0.232
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 1 - inactivation of fast Na+ channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 1 - inactivation of fast Na+ channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
2
3
80.6
self reported educational attainment
1
1
1
72.5
cognitive function measurement
1
1
1
35
response to angiotensin-converting enzyme inhibitor
1
1
0
1.2
33.1
Cough
1
1
0
1.2
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
3
80.6
self reported educational attainment
1
72.5
cognitive function measurement
1
35
response to angiotensin-converting enzyme inhibitor
0
1.2
33.1
Cough
0
1.2
33.1
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel interacting protein 4
VGNC:48912
471155
Mouse
MGI:1933131
80334
Rat
RGD:708539
259243
Dog
potassium voltage-gated channel interacting protein 4
VGNC:42257
479129
Horse
potassium voltage-gated channel interacting protein 4
VGNC:19282
100147377
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel interacting protein 4
Mouse
Rat
Dog
potassium voltage-gated channel interacting protein 4
Horse
potassium voltage-gated channel interacting protein 4
Publication Statistics
PubMed Score 107.52
PubMed score by year
PubTator Score 17.90
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title