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Tbio
KCNIP2
Kv channel-interacting protein 2

Protein Summary
Description
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity). This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript var ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239117
  • ENSP00000239117
  • ENSG00000120049
  • ENST00000343195
  • ENSP00000344169
  • ENST00000348850
  • ENSP00000239118
  • ENST00000353068
  • ENSP00000341624
  • ENST00000356640
  • ENSP00000349055
  • ENST00000358038
  • ENSP00000350733
  • ENST00000434163
  • ENSP00000411679
  • ENST00000461105
  • ENSP00000420040

Symbol
  • KCHIP2
  • KCHIP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.84
protein domain
0.73
virus perturbation
0.72
gene perturbation
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.79   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 384   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.79   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (85)
KCNIP4
Tbio
Family:  IC
Novelty:  0.00973829
p_int:  1
Score:  0.767
Data Source:  BioPlex,Reactome,STRINGDB
KCNIP1
Tbio
Family:  IC
Novelty:  0.01790042
p_int:  0.999999581
p_ni:  4e-9
p_wrong:  4.15e-7
Score:  0.876
Data Source:  BioPlex,Reactome,STRINGDB
WBP1
Tbio
Novelty:  1.24967974
p_int:  0.999801234
p_ni:  0.000198746
p_wrong:  1.9e-8
Score:  0.278
Data Source:  BioPlex,STRINGDB
STK17B
Tchem
Family:  Kinase
Novelty:  0.0420158
p_int:  0.998804033
p_ni:  0.000988614
p_wrong:  0.000207353
Score:  0.344
Data Source:  BioPlex,STRINGDB
REEP2
Tdark
Novelty:  0.23897587
p_int:  0.98197092
p_ni:  0.017939641
p_wrong:  0.000089439
Score:  0.375
Data Source:  BioPlex,STRINGDB
S100A7
Tbio
Novelty:  0.00434262
p_int:  0.815207794
p_ni:  0.184792206
Score:  0.187
Data Source:  BioPlex,STRINGDB
ANKRD13A
Tbio
Novelty:  0.61940334
p_int:  0.786501809
p_ni:  0.213498191
Score:  0.696
Data Source:  BioPlex,STRINGDB
KCND3
Tclin
Family:  IC
Novelty:  0.00328276
Score:  0.998
Data Source:  Reactome,STRINGDB
KCND2
Tclin
Family:  IC
Novelty:  0.00297203
Score:  0.997
Data Source:  Reactome,STRINGDB
KCND1
Tclin
Family:  IC
Novelty:  0.03738277
Score:  0.977
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Phase 1 - inactivation of fast Na+ channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Phase 1 - inactivation of fast Na+ channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (24)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
5
3
7.2
86.9
self reported educational attainment
3
3
3
84.3
mathematical ability
4
2
4
80.4
household income
1
3
3
73.8
cognitive function measurement
2
1
2
68.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
7.2
86.9
self reported educational attainment
3
84.3
mathematical ability
4
80.4
household income
3
73.8
cognitive function measurement
2
68.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel interacting protein 2
VGNC:4719
745263
Macaque
potassium voltage-gated channel interacting protein 2
712434
Mouse
MGI:2135916
80906
Rat
RGD:70887
56817
Dog
potassium voltage-gated channel interacting protein 2
VGNC:42255
403598
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel interacting protein 2
Macaque
potassium voltage-gated channel interacting protein 2
Mouse
Rat
Dog
potassium voltage-gated channel interacting protein 2
Publication Statistics
PubMed Score 95.79
PubMed score by year
PubTator Score 47.67
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title