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Tbio
KCNIP2
Kv channel-interacting protein 2

Protein Summary
Description
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. May be required for the expression of I(To) currents in the heart (By similarity). This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belongs to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Multiple alternatively spliced transcript var ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000239117
  • ENSP00000239117
  • ENSG00000120049
  • ENST00000343195
  • ENSP00000344169
  • ENST00000348850
  • ENSP00000239118
  • ENST00000353068
  • ENSP00000341624
  • ENST00000356640
  • ENSP00000349055
  • ENST00000358038
  • ENSP00000350733
  • ENST00000434163
  • ENSP00000411679
  • ENST00000461105
  • ENSP00000420040

Symbol
  • KCHIP2
  • KCHIP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
kinase perturbation
0.84
protein domain
0.73
virus perturbation
0.72
gene perturbation
0.65


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.18   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 384   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 101.18   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 384   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0