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Tclin
KCNH7
Potassium voltage-gated channel subfamily H member 7

Protein Summary
Description
Pore-forming (alpha) subunit of voltage-gated potassium channel. Channel properties may be modulated by cAMP and subunit assembly. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. There are at least two alternatively spliced transcript variants derived from this gene and encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000328032
  • ENSP00000333781
  • ENSG00000184611
  • ENST00000332142
  • ENSP00000331727

Symbol
  • ERG3
  • ERG3
  • HERG3
  • Kv11.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
molecular function
0.88
trait
0.86
virus perturbation
0.76
hub protein
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.78   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 156   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.78   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 156   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (33)
KCNAB3
Tbio
Family:  IC
Novelty:  0.10128237
Score:  0.941
Data Source:  STRINGDB
KCNAB2
Tbio
Family:  IC
Novelty:  0.01752175
Score:  0.924
Data Source:  STRINGDB
KCNAB1
Tbio
Family:  IC
Novelty:  0.01413705
Score:  0.924
Data Source:  STRINGDB
GCA
Tbio
Novelty:  0.01485875
Score:  0.725
Data Source:  STRINGDB
SLC4A10
Tbio
Family:  Transporter
Novelty:  0.02669548
Score:  0.64
Data Source:  STRINGDB
GATD1
Tdark
Family:  Enzyme
Novelty:  0.40291197
Score:  0.6
Data Source:  STRINGDB
IFIH1
Tbio
Family:  Enzyme
Novelty:  0.00111499
Score:  0.589
Data Source:  STRINGDB
PRL
Tbio
Novelty:  0.0000905
Score:  0.583
Data Source:  STRINGDB
SPHKAP
Tbio
Family:  Enzyme
Novelty:  0.19137014
Score:  0.555
Data Source:  STRINGDB
ODF4
Tbio
Novelty:  0.13423621
Score:  0.514
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (42)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Potassium Channels
Reactome
Voltage gated Potassium channels
Name
Explore in Pharos
Explore in Source
Neuronal System
Potassium Channels
Voltage gated Potassium channels
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
2
0
1.3
82.4
2
2
1
1.2
72.8
psoriasis vulgaris
1
1
0
1.3
56.8
high density lipoprotein cholesterol measurement
1
1
1
15.8
cigarettes per day measurement
1
1
1
1.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
82.4
1
1.2
72.8
psoriasis vulgaris
0
1.3
56.8
high density lipoprotein cholesterol measurement
1
15.8
cigarettes per day measurement
1
1.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily H member 7
VGNC:8358
470573
Macaque
potassium voltage-gated channel subfamily H member 7
702259
Mouse
MGI:2159566
170738
Rat
RGD:621112
170739
Dog
potassium voltage-gated channel subfamily H member 7
VGNC:42252
478768
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium voltage-gated channel subfamily H member 7
Macaque
potassium voltage-gated channel subfamily H member 7
Mouse
Rat
Dog
potassium voltage-gated channel subfamily H member 7
Publication Statistics
PubMed Score 10.78
PubMed score by year
PubTator Score 10.85
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text