Tclin KCNH6 Potassium voltage-gated channel subfamily H member 6

Protein Summary

Description

Pore-forming (alpha) subunit of voltage-gated potassium channel. Elicits a slowly activating, rectifying current (By similarity). Channel properties may be modulated by cAMP and subunit assembly. Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, subfamily H. This member is a pore-forming (alpha) subunit. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]

Uniprot Accession IDs

• Q9H252
• Q9BRD7

Gene Name

• KCNH6

Ensembl ID

• ENST00000456941
• ENSP00000396900
• ENSG00000173826
• ENST00000580652
• ENSP00000464672
• ENST00000581784
• ENSP00000463830
• ENST00000583023
• ENSP00000463533

Symbol

• ERG2
• ERG2
• ERG-2
• HERG2
• Kv11.2
• hERG-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
molecular function	0.81
cell type or tissue	0.7
cell line	0.53
tissue	0.5

Protein Classes

DTO Classes

Protein / Ion Channel / Potassium Channel Family / H (Eag) Subfamily / Kv11.2/kcnh6 Sub-subfamily / Potassium Voltage-gated Channel Subfamily H Member 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.58   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 121   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.58   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3